State-of-the-science of endocrine disrupting chemicals, 2012

Bergman, Åke; Heindel, Jerrold J.; Jobling, Susan; Kidd, Karen A.; Zoeller, R. Thomas

doi:10.1016/j.toxlet.2012.03.020

Cited by 545 publications

(516 citation statements)

References 875 publications

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“…The causal factors therefore appeared to be existing in all parts of the country, which could be consistent with a global change in environmental exposure, especially according to the endocrine disruptor hypothesis Source: IGN-GéoFLA, 2008;FIVNAT, 1989FIVNAT, -2005InVS, 2013. (Bergman et al 2012), and/or in lifestyle. However, the results at the regional level do not appear to support the lifestyle hypothesis.…”

Section: Resultsmentioning

confidence: 99%

“…As in most developed countries, the French population has been exposed to a growing number of chemicals via diverse routes of exposure since the 1950s. More than 800 substances are now suspected to be endocrine disruptor chemicals (EDCs; Bergman et al 2012). Main EDCs are now found in biological matrices of French people (Casas et al 2012, Frery 2013, some (non-dioxin-like PCB, pesticides and triclosan) at a level higher than that in other countries.…”

Section: Links With Possible Factorsmentioning

confidence: 99%

“…These robust results regarding temporal trends constitute a serious public health warning. The endocrine disruptor hypothesis, strengthened by accumulating evidence lately (Bergman et al 2012), may partly explain such trends. Changes in lifestyle are other identified factors (Sharpe 2010).…”

Section: Introductionmentioning

confidence: 99%

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Semen quality trends in French regions are consistent with a global change in environmental exposure

Moal¹,

Rolland²,

Goria³

et al. 2014

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A retrospective study carried out recently in a large sample of men, close to the general population, has reported a significant and strong decline in sperm concentration and morphology in the whole of France between 1989 and 2005. We studied these trends within each region of France. Data were obtained from the Fivnat database. The study sample comprised male partners of sterile women in whom both tubes were absent or blocked. They were located at the assisted reproductive technology center. A Bayesian spatio-temporal model with parametric time trends, adjusted for age, was used to model overall time trends for each region. The results show that sperm concentration decreased in almost all regions of France. Among them, Aquitaine showed the highest decrease and Midi-Pyrénées had the lowest average for the whole period. Regarding total motility, most regions showed a slight increase while Bourgogne showed a steep and significant decrease. While considering sperm morphology, there was a decrease in most of the regions. The decrease in Aquitaine and Midi-Pyrénées was stronger when compared with the overall trend. In conclusion, a decrease in sperm concentration and morphology, already shown at the French metropolitan territory level, was observed in most regions of France. This is consistent with a global change in environmental exposure, according to the endocrine disruptor hypothesis especially. Indeed, ubiquitary exposure to chemicals has been growing in the general population of France since the 1950s, and the results do not appear to support the lifestyle hypothesis. The highest decreases and lowest values are consistently observed in two proximate regions that are both highly agricultural and densely populated.

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Section: Resultsmentioning

confidence: 99%

Section: Links With Possible Factorsmentioning

confidence: 99%

See 1 more Smart Citation

Semen quality trends in French regions are consistent with a global change in environmental exposure

Moal¹,

Rolland²,

Goria³

et al. 2014

Reproduction

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“…In the past few years a correlation has been found between sudden infant death syndrome (SIDS) and sudden unexpected death syndrome intrauterine (SIUDS) with exposure to EDC indicating growing serious problems in this matter [34][35][36][37]. Both of these syndromes are among the most important causes of death in fetuses and neonates in developed countries.…”

Section: Endocrine Disrupting Compoundsmentioning

confidence: 99%

Research trends on emerging environment pollutants – a review

Rykowska

Wasiak

2015

Open Chemistry

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Concern for the natural environment increasingly devotes more attention to growing potential hazards resulting from the release of various substances. Currently, one of the main problems associated with environmental pollution is the derivation of organic compounds from wastewater. Substances derived from sewage leaks into the environment in the form of a multicomponent mixtures often enhances the toxic effects caused by these compounds. While analyzing the reports in the literature of the last two decades it can be seen that substantial efforts are devoted to the determination of selected trace contaminants present in wastewater. Among the most marked there are endocrine disrupting compounds, residues of pharmaceuticals and personal care products, plastics and sunscreens. Recently, a new group of compounds joined the aforementioned contaminants, namely drugs, whose legality and availability is increasing every year. Exposure to these type of compounds, named in the literature as emerging contaminants (ECs), involves, among others, such effects as hormonal imbalance, reduction of the survivability of aquatic organisms and reproductive problems.This paper provides a review of the types of emerging organic groundwater contaminants (EGCs) which are beginning to be found in the natural environment in many countries all around the world.

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“…Dispersed oil, aromatic hydrocarbons and alkylphenols (AP), heavy metals, and naturally occurring radioactive material (NORM) raise major environmental concerns in the public [3]. Some of the toxicants are acutely toxic, some are carcinogenic, and others are endocrine-disruptor [4][5][6][7] for microorganisms as well as human beings in the ecosystem system. Enormous technologies have been developed to address the adverse environmental impacts of the PW and DW by improving treatment process and technologies for disposal and reuse purposes.…”

Section: Introductionmentioning

confidence: 99%