The objective of this study was to examine the contributing role of socio-economic status on adherence to directives from the Indigenous People of Biafra (IPOB) separatist group. A descriptive survey was used for the study, while 325 participants were sampled using the respondents’ chain referral sampling technique. The study showed that socio-economic factors such as income, education and employment status contribute 35.5% to determine compliance with IPOB directives. The results of the multiple regression analysis achieved a statistical significance, R2 = 0.355, p = 0.001, F(3,310) = 51.524. Finally, we explored the implication of these results on Integrated Separatist Agitation Theory and highlighted the scholarly and practical implications.