2002
DOI: 10.1016/s0002-9440(10)64866-3
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Stathmin-Deficient Mice Develop an Age-Dependent Axonopathy of the Central and Peripheral Nervous Systems

Abstract: Stathmin is a cytosolic protein that binds tubulin and destabilizes cellular microtubules, an activity regulated by phosphorylation. Despite its abundant expression in the developing mammalian nervous system and despite its high degree of evolutionary conservation, stathmin-deficient mice do not exhibit a developmental phenotype.

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Cited by 94 publications
(84 citation statements)
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“…Conversely, microtubules can be destabilized by proteins such as stathmin (review in Cassimeris, 2002). The critical role of stathmin in the maintenance of axonal integrity has been demonstrated in stathmin-deficient mice (Liedtke et al, 2002). The downregulation of stathmin observed here represents the first report of its modulation by chronic morphine treatment in vivo.…”
Section: Discussionmentioning
confidence: 59%
“…Conversely, microtubules can be destabilized by proteins such as stathmin (review in Cassimeris, 2002). The critical role of stathmin in the maintenance of axonal integrity has been demonstrated in stathmin-deficient mice (Liedtke et al, 2002). The downregulation of stathmin observed here represents the first report of its modulation by chronic morphine treatment in vivo.…”
Section: Discussionmentioning
confidence: 59%
“…Drosophila mutants that are hypomorphic for stathmin 1 exhibit strong cell migration and axonal pathfinding phenotypes (Ozon et al, 2002), and aging Stathmin 1-null mice exhibit axonal degeneration (Liedtke et al, 2002). Oligodendrocyte process outgrowth is regulated by stathmin 1 in vitro, whereby lowering the activity of this protein promotes microtubule stability as well as process extension and branching (Liu et al, 2003).…”
Section: Discussionmentioning
confidence: 99%
“…After brain trauma, stathmin levels increase (19,20), as they do during axonal and dendritic growth (21,27). The particular significance of stathmins to the CNS is further supported by the observations that stathmin-deficient mice show defects in innate and acquired fear (28) and selectively develop axonopathy at advanced age (29). Drosophila flies in which the stathmin gene has been knocked down by siRNAs develop widespread defects in the nervous system only (30).…”
Section: Figurementioning
confidence: 91%