Non-composite steel-concrete-steel panels develop high load-carrying capacity through the tensile membrane resistance of the steel faceplates at large displacement. The response of a full-scale barrier structure composed of the non-composite SCS panels and steel posts under various blast loading scenarios was investigated using non-linear finite element software LS-Dyna. The simulation results showed that the barrier was able to withstand very large blast energy. It can be concluded that non-composite SCS panels can provide an attractive solution to expedite construction of high-performance protective barriers to resist extreme blast loadings.