This study employed the linear interpolation method to ascertain the curve relationship between the elastic modulus and stress of high-strength concrete C60 with temperature, and the nonlinear dynamic analysis of high-strength concrete bridge structures subjected to post-fire earthquake action at varying water levels was subsequently evaluated. It was established that both the hydrodynamic effects and the temperature effects have a considerable impact on the structural dynamic response of bridges. The presence of water has been observed to increase the dynamic response of pier structures. At water levels of 0 m and 10 m, the temperature effect results in a reduction in the fundamental frequencies of acceleration and displacement responses by 73.68% and a decrease in the fundamental frequency of stress responses by 83.33%. At a water level of 20 m, the fundamental frequencies of the acceleration, displacement, and stress responses decrease by 53.49%. In consideration of the acceleration and displacement at the pier top and stress at the pier base at a water depth of 10 m, the superposition of temperature effects and hydrodynamic effects results in an increase of 59.06% in acceleration, 25.93% in displacement, and 49.53% in stress than combination effects, respectively. At a water depth of 20 m, the superposition of temperature and hydrodynamic effects results in an increase of 92.82%, 100%, and 127.85% in acceleration, displacement, and stress, respectively. The combined effects of hydrodynamic and temperature effects cannot be described merely as a linear superposition of the two single actions. The research findings provide a significant theoretical basis for understanding the impact of multiple disasters, such as fires and earthquakes, on bridge structures.