“…Relatively short consolidation periods chosen in the present study are based on previous experiments 17,25 . Although the absence of statistical significance among different consolidation periods was demonstrated previously by intact calvarial bone, 15,16 the cortical bone perforation might possibly enhance the differences with time 32 . The only exception in the present study is observed in the group without membrane in region R2a.…”
Section: Discussionmentioning
confidence: 49%
“…In contrast to the conventional DO, the distraction cavity is bordered by the original surface of the bone base and the periosteal (i.e., cambial) layer when a gradual distraction of the periosteum is applied. By application of perforated distraction plates or meshes in different models of periosteal distraction osteogenesis (PDO), new bone was formed to varying extents 9‐17 . Sencimen et al 18 found significant differences in the extent of newly formed bone between conventional DO and PDO disclosed by high content of interstitial fatty tissue.…”
Within the limitations of the present study, the application of a barrier membrane may be considered beneficial for new bone formation induced by periosteal distraction.
“…Relatively short consolidation periods chosen in the present study are based on previous experiments 17,25 . Although the absence of statistical significance among different consolidation periods was demonstrated previously by intact calvarial bone, 15,16 the cortical bone perforation might possibly enhance the differences with time 32 . The only exception in the present study is observed in the group without membrane in region R2a.…”
Section: Discussionmentioning
confidence: 49%
“…In contrast to the conventional DO, the distraction cavity is bordered by the original surface of the bone base and the periosteal (i.e., cambial) layer when a gradual distraction of the periosteum is applied. By application of perforated distraction plates or meshes in different models of periosteal distraction osteogenesis (PDO), new bone was formed to varying extents 9‐17 . Sencimen et al 18 found significant differences in the extent of newly formed bone between conventional DO and PDO disclosed by high content of interstitial fatty tissue.…”
Within the limitations of the present study, the application of a barrier membrane may be considered beneficial for new bone formation induced by periosteal distraction.
“…Exfoliated and returned periosteum promotes the process of new bone formation 30 by the mutual interaction of the bone matrix and osteoprogenitor cells in the periosteum. 1,24,25 Several factors may be attributed to the lack of significant differences between the groups for region R3. In the present study, the true viability of the periosteum was not evaluated.…”
If the marrow cavities were not opened, the contribution to new bone formation was dominant from the periosteum. If the bone perforations opened the marrow cavities, a significant contribution to new bone formation originated from the native bone.
“…Alternatively, less invasive methods to create a surplus of soft tissues, and therefore reduce the risk for mucosal dehiscences, have been investigated: periosteal distraction (Schmidt et al 2002;Kessler et al 2007;Sencimen et al 2007;Oda et al 2009;Tudor et al 2010) and tissue engineered periosteum (Sch€ onmeyr et al 2009;Warnke et al 2009). In spite of the promising results, these methods are still experimental and have been tested only in animal experiments.…”
Further clinical trials with larger sample sizes and long-term follow-up are needed before soft tissue expanders can be confidently applied in everyday clinical practice.
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