During earthquake, reinforced concrete walls show complicated post-yield behavior varying with shear span-to-depth ratio, re-bar detail, and loading condition. In the present study, a macro-model for the nonlinear analysis of multi-story wall structures was developed. To conveniently describe the coupled flexure-compression and shear responses, a reinforced concrete wall was idealized with longitudinal and diagonal uniaxial elements. Simplified cyclic material models were used to describe the cyclic behavior of concrete and re-bars. For verification, the proposed method was applied to various existing test specimens of isolated and coupled walls. The results showed that the predictions agreed well with the test results including the load-carrying capacity, deformation capacity, and failure mode. Further the proposed model was applied to an existing wall structure tested on a shaking table. Three-dimensional nonlinear time history analyses using the proposed model were performed for the test specimen. The time history responses of the proposed method agreed with the test results including the lateral displacements and base shear.