Static Magnetic Field Attenuates Lipopolysaccharide‐Induced Inflammation in Pulp Cells by Affecting Cell Membrane Stability

Hsieh, Sung Chih; Tsao, Jeng Ting; Lew, Wei Zhen; Chan, Ya Hui; Lee, Lin Wen; Lin, Che Tong; Huang, Yung Kai; Huang, Haw Ming

doi:10.1155/2015/492683

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…Pseudomonas aeruginosa LPS has a toxic effect on DPSCs in a dose-dependent manner [ 95 ]. Pretreatment with static magnetic field (SMF) attenuates inflammatory response and increases viability of cells.…”

Section: Resultsmentioning

confidence: 99%

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Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis—A Systematic Review

et al. 2022

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Lipopolysaccharide (LPS) is widely used for induction of inflammation in various human tissues, including dental pulp. The purpose of this study was to summarize current medical literature focusing on (1) cell types used by researchers to simulate dental pulp inflammation, (2) LPS variants utilized in experimental settings and how these choices affect the findings. Our study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). We searched for studies reporting outcomes of lipopolysaccharide application on dental pulp cells in vitro using electronic databases: MEDLINE, Web of Science and Scopus. Having gathered data from 115 papers, we aimed to present all known effects LPS has on different cell types present in dental pulp. We focused on specific receptors and particles that are involved in molecular pathways. Our review provides an essential foundation for further research using in vitro models of pulpitis.

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Section: Resultsmentioning

confidence: 99%

“…Pretreatment with static magnetic field (SMF) attenuates inflammatory response and increases viability of cells. SMF can also enhance the proliferation of DPSCs [ 95 ].…”

Section: Resultsmentioning

confidence: 99%

Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis—A Systematic Review

et al. 2022

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“…LPS-induced dental pulp inflammation represents a stable experimental inflammation model for the dynamic observation of the progress of acute and chronic pulpitis, as well as other oral inflammatory diseases in rodents [ 27 , 34 ]. Previous studies have shown that LPS-treated inflammation is induced in a time- and dose-dependent manner in dental pulp cells [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

Anti‐Inflammatory Effects of Melatonin and 5‐Methoxytryptophol on Lipopolysaccharide‐Induced Acute Pulpitis in Rats

Basmacı¹,

Aksoy²,

Sebai³

et al. 2021

BioMed Research International

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Aim. The aim of this study was to investigate the possible therapeutic impacts of two pineal hormones, melatonin and 5-methoxytryptophol (5-MTX), in a rat model of acute pulpitis by analyzing biochemical and histopathological parameters. Methods. This research was done using 32 male and female Wistar albino rats with weight between 200 and 250 g. The rats were randomly divided into four groups: a control group (rats without any treatment), acute pulpitis (AP) group, AP+melatonin group, and AP+5-MTX group. In the AP-induced groups, the crowns of the upper left incisors were removed horizontally. Lipopolysaccharide solution was applied to the exposed pulp tissue before the canal orifices were sealed with a temporary filling material. Melatonin (10 mg/kg) and 5-MTX (5 mg/kg) were administered intraperitoneally. The rats were sacrificed 24 hours after pulp injury, and trunk blood and pulp samples were collected. The concentrations of TNF-α, IL-1β, MMP-1, and MMP-2 in sera and pulp samples were determined using ELISA assay kits. Results. TNF-α, IL-1β, MMP-1, and MMP-2 levels in the serum and pulp tissues were considerably higher in the AP group than the control group ( p < 0.01 ‐ 0.001 ). In the AP+melatonin and AP+5-MTX groups, TNF-α, IL-1β, MMP-1, and MMP-2 levels in the serum and pulp tissues were significantly lower than in the AP group ( p < 0.05 ‐ 0.001 ). Conclusions. Both melatonin and 5-MTX provided protective effects on acute pulpitis, which indicates they may be promising as a therapeutic strategy for oral disease.

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“…Tooth pulp developing from dental papilla consists of odontoblast, fibroblast, blood, and neural veins [17]. Odontoblast cells are the most important cells of the pulp.…”

Section: Dental Pulpmentioning

confidence: 99%

Relation of Trace Elements on Dental Health

Doğan¹

2018

Trace Elements - Human Health and Environment

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Trace elements (TEs) play an important role in human health. Toxic effects are caused by deficiency or excess of TEs. TEs have significant effects on both dental health and human health. It participates in important biological polyphosphate compound functions such as ATP, DNA, and RNA. TEs are present at different concentrations in the tooth structure. Changes in the density of some TEs affect tooth. The alteration of the density of some TEs makes the teeth more susceptible to caries. Others are protective against caries formation. Important TEs zinc (Zn), phosphorus (P), and magnesium (Mg) have important effects on dental health. Measuring the TE values through tissue sampling to identify and correct these effects has an important effect. In general, tissue samples such as blood, urine, teeth, nails, and hair are used in TE studies. Teeth are accepted as appropriate indication of TEs. As a result, TEs have significant effects on healthy tooth formation.

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Static Magnetic Field Attenuates Lipopolysaccharide‐Induced Inflammation in Pulp Cells by Affecting Cell Membrane Stability

Cited by 11 publications

References 36 publications

Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis—A Systematic Review

Role of Lipopolysaccharide, Derived from Various Bacterial Species, in Pulpitis—A Systematic Review

Anti‐Inflammatory Effects of Melatonin and 5‐Methoxytryptophol on Lipopolysaccharide‐Induced Acute Pulpitis in Rats

Relation of Trace Elements on Dental Health

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