Static Magnetic Field Exposure In Vivo Enhances the Generation of New Doublecortin-expressing Cells in the Sub-ventricular Zone and Neocortex of Adult Rats

Yakir-Blumkin, Moriya Ben; Loboda, Yelena; Schächter, Levi; Finberg, J. P. M.

doi:10.1016/j.neuroscience.2019.11.005

Cited by 9 publications

(6 citation statements)

References 117 publications

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“…Numerous studies have shown that non-uniform magnetic fields can introduce variations in the response of biological systems, affecting the results of controlled biotechnological experiments [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ]. By addressing non-uniformity through polygonal coil designs and dimension adjustments, the understanding and applicability of electromagnetic technologies in various biotechnology studies can be advanced [ 21 , 22 , 23 ].…”

Section: Resultsmentioning

confidence: 99%

“…Recent research indicates that electromagnetic fields can stimulate or inhibit different biological systems [ 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ], such as the growth of plants [ 13 ], fruits [ 14 ], and microorganisms [ 15 ]. Similarly, they affect cells in the human [ 16 ] and animal [ 17 ] body by stimulating or inhibiting different cellular processes [ 18 ]. Several of these cellular properties have been used to improve health [ 4 ], obtain metabolites of industrial interest [ 5 ], and remove contaminants from soil [ 6 ], water [ 7 ], and air [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, researchers have begun to investigate the potential impact of EMFs on fermentative processes. Although the role and influence of the magnetic field in this process are undeniable, there are many aspects to consider about its effects [ 12 ], which still need to be sufficiently understood [ 4 , 5 , 6 , 7 , 12 , 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Experimental Prototype of Electromagnetic Emissions for Biotechnological Research: Monitoring Cocoa Bean Fermentation Parameters

Guzmán-Armenteros

Ruales

Villacís-Chiriboga

et al. 2023

Foods

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A Helmholtz-type electromagnetic emission device, which uses an oscillating magnetic field (OMF), with potential applications in biotechnological research, was built and validated. The coils were connected to an alternating current (AC) generator to generate a 0.5 to 110 mT field at their center. OMF measurements were performed with a Hall effect sensor with a digital signal connection (Arduino nano) and data output to a PC using LabVIEW v2017SP1 software. The fermentation process of the cocoa bean variety CCN 51, exposed to four levels of OMF density for 60 min (0, 5, 40, and 80 mT/60 min), was analyzed. Different variables of the grain fermentation process were evaluated over six days. The ANOVA test probed the device’s linearity, accuracy, precision, repeatability, reliability, and robustness. Moreover, CCN 51 cocoa beans’ EMF-exposure effect was evaluated under different OMF densities for 60 min. The results show the validity of the equipment under working conditions and the impact of EMF (electromagnetic fields) on the yield, deformation, and pH of cocoa beans. Thus, we concluded that the operation of the prototype is valid for use in biotechnological studies.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Experimental Prototype of Electromagnetic Emissions for Biotechnological Research: Monitoring Cocoa Bean Fermentation Parameters

Guzmán-Armenteros

Ruales

Villacís-Chiriboga

et al. 2023

Foods

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“…For example, Ben Yakir-Blumkin et al found that continuous exposure of young adult rats to low-intensity SMFs of <10 mT for 3 weeks significantly enhanced the generation of new doublecortin-expressing cells in the sub-ventricular zone (SVZ) and neocortex. 49 Exposure of rat olfactory ensheathing cells (OECs) to 30, 50, and 70 mT SMFs led to filamentous pseudopod formation, cell morphology changes and cell migration promotion. 50 Nakamichi et al discovered that 100 mT SMF considerably reduced cell proliferation of neural progenitor cells (NPCs) and promoted their differentiation into neurons.…”

Section: Nerve Cellsmentioning

confidence: 99%

Static magnetic fields in regenerative medicine

Xie,

Song,

Guo

et al. 2024

APL Bioengineering

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All organisms on Earth live in the weak but ubiquitous geomagnetic field. Human beings are also exposed to magnetic fields generated by multiple sources, ranging from permanent magnets to magnetic resonance imaging (MRI) in hospitals. It has been shown that different magnetic fields can generate various effects on different tissues and cells. Among them, stem cells appear to be one of the most sensitive cell types to magnetic fields, which are the fundamental units of regenerative therapies. In this review, we focus on the bioeffects of static magnetic fields (SMFs), which are related to regenerative medicine. Most reports in the literature focus on the influence of SMF on bone regeneration, wound healing, and stem cell production. Multiple aspects of the cellular events, including gene expression, cell signaling pathways, reactive oxygen species, inflammation, and cytoskeleton, have been shown to be affected by SMFs. Although no consensus yet, current evidence indicates that moderate and high SMFs could serve as a promising physical tool to promote bone regeneration, wound healing, neural differentiation, and dental regeneration. All in vivo studies of SMFs on bone regeneration and wound healing have shown beneficial effects, which unravel the great potential of SMFs in these aspects. More mechanistic studies, magnetic field parameter optimization, and clinical investigations on human bodies will be imperative for the successful clinical applications of SMFs in regenerative medicine.

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“…Clinical application of SMF has shown to positively influence a broad range of physiological processes including; pain relief (Pittler et al., 2007), bone repair (J. Zhang et al., 2014), nervous functioning (Yakir‐Blumkin et al., 2020), and wound healing (Ebrahimdamavandi & Mobasheri, 2019; Zhao et al., 2017). The SMF has been reported to have effects on cellular structure (Teodori et al., 2006).…”

Section: Introductionmentioning

confidence: 99%

Static magnetic field modulates olfactory ensheathing cell's morphology, division, and migration activities, a biophysical approach to regeneration

Elyasigorji

Mobasheri

Dini

2022

J Tissue Eng Regen Med

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The moderate static magnetic fields (SMFs) have been used here as a non-invasive tool to study their manipulative effects on the olfactory ensheathing cells (OECs) activity, growth, morphology, and migration in culture. The OECs are involved in the regeneration of primary olfactory sensory neurons and migration into the central nervous system to repair axons damaged by infection, injury, etc., that play a pivotal role in complementary regenerative medicine. Here, OECs were isolated from the olfactory bulb and cultured to confluence. An in vitro wound healing model was formed and exposed to either parallel (PaSMF) or perpendicular (PeSMF) SMF at intensities of 30, 50, and 70 mT, and cells' morphology, podia formation, proliferation, and migration were studied by time-lapse recording. The SMFs were not cytotoxic at the intensity and exposure time applied here. The exposure of cells to 70 mT PaSMF and PeSMF increased the formation of lamellipodia and filopodia, cell migration speed, and direction of the scratch forefront cells, significantly. Treatment of cells with 70 mT PaSMF and PeSMF increased cell divisions, while 30 mT PaSMFdecreased it. SMF effects on OECs division, motility, migratory direction, and velocity indicate its effect on various aspects of cell physiology and signaling at atomic and molecular levels, and have a role in tissue regeneration that involves microtubules and actin filaments formation and rearrangements. Thus, the exposure of OECs with moderate SMF might be considered a promising noninvasive approach to remotely manipulate normal and stem cell activities for therapeutic regenerative purposes in various tissues including the central nervous system.

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Static Magnetic Field Exposure In Vivo Enhances the Generation of New Doublecortin-expressing Cells in the Sub-ventricular Zone and Neocortex of Adult Rats

Cited by 9 publications

References 117 publications

Experimental Prototype of Electromagnetic Emissions for Biotechnological Research: Monitoring Cocoa Bean Fermentation Parameters

Experimental Prototype of Electromagnetic Emissions for Biotechnological Research: Monitoring Cocoa Bean Fermentation Parameters

Static magnetic fields in regenerative medicine

Static magnetic field modulates olfactory ensheathing cell's morphology, division, and migration activities, a biophysical approach to regeneration

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