a b s t r a c tWhen the uncertainties in interval parameters are fairly large, the current analysis methods, which are usually based on the information of the first-order partial derivatives of eigenvalues, may not work well for the structural eigenvalue problem with interval parameters. To overcome this drawback, in this work, the structural eigenvalue problem with interval parameters is modeled as a series of QB (quadratic programming with box constrains) problems by taking advantage of the information of the second-order partial derivatives of eigenvalues. Then the series of QB problems would be solved by using the DCA (difference of convex functions algorithm) which is turn out be very effective for the QB problem. The specific examples, a concrete frame with sixty bars and a plate discretized with 300 finite elements, are given to show the effectiveness and feasibility of the proposed method compared with other methods.