2016
DOI: 10.11622/smedj.2016118
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Statin-centric versus low-density lipoprotein-centric approach for atherosclerotic cardiovascular disease prevention: a Singapore perspective

Abstract: The link between cholesterol levels and atherosclerotic cardiovascular disease (ASCVD) is well-established.In Singapore, there is an increasing prevalence of risk factors for ASCVD. Like many Asian countries, Singapore's population is rapidly ageing and increasingly sedentary, which predisposes individuals to chronic health problems. Current international and local guidelines recommend statin therapy for the primary and secondary prevention of ASCVD. However, despite the effectiveness of statin therapy, some s… Show more

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Cited by 7 publications
(9 citation statements)
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“…Angiotensin-converting enzyme (ACE) inhibitor should be prescribed early as chronic kidney disease (CKD) prevention is both cost and time effective. WHO has recommended metformin, sulfonylurea, insulin, aspirin, statin, ACE inhibitor, angiotensin receptor blocker (ARB), and thiazide as the essential medications for the management of diabetes and related NCDs 4952…”
Section: Background Informationmentioning
confidence: 99%
“…Angiotensin-converting enzyme (ACE) inhibitor should be prescribed early as chronic kidney disease (CKD) prevention is both cost and time effective. WHO has recommended metformin, sulfonylurea, insulin, aspirin, statin, ACE inhibitor, angiotensin receptor blocker (ARB), and thiazide as the essential medications for the management of diabetes and related NCDs 4952…”
Section: Background Informationmentioning
confidence: 99%
“… 55 Atorvastatin (10–80 mg) has been found to be equally efficacious and safe in Asian and Western populations. 56 , 57 Therefore, there is no regulatory warning about the dose of atorvastatin in Asians. 57 …”
Section: Role Of Statins In the Prevention Of Cvdmentioning
confidence: 99%
“…(13) The data collected in DYSIS II supports the observation that hyperlipidaemia appears to be a significant issue in Singapore. With the increasing prevalence of other cardiovascular risk factors, including obesity and Type 2 DM, (4) rates of adverse events are likely to increase rapidly if more effective management is not implemented.…”
Section: Discussionmentioning
confidence: 99%
“…(2,3) With rising levels of obesity and Type 2 diabetes mellitus (DM), the situation is set to get worse over the coming years. (4) Effective management of the risk factors associated with CHD is therefore essential for reducing the burden of cardiovascular disease in Singapore.…”
Section: Introductionmentioning
confidence: 99%