Statin Therapy Ameliorates Renal Allograft Function

Hariparshad, Sudesh; Madala, Nomandla; Assounga, Alain

doi:10.1016/j.transproceed.2009.08.075

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…In ALERT study, fluvastatin could not prevent a decline in renal function or graft loss [ 43 ]. However, other studies have demonstrated a significant benefit of statins on graft function [ 44 – 46 ]. In the present study, better renal graft function in the statin group compared to the control group was observed.…”

Section: Discussionmentioning

confidence: 99%

Effect of Statins on the Progression of Coronary Calcification in Kidney Transplant Recipients

et al. 2016

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BackgroundCoronary calcification (CAC) is highly prevalent in kidney transplant recipients (KTRs) and has been associated with cardiovascular morbidity and mortality. Some studies have shown a reduction in CAC progression with statin therapy in the general and chronic kidney disease (CKD) populations.Objectives and MethodsThe aim of the present study was to evaluate the effect of statins on CAC progression in incident kidney transplant recipients. Patients were randomly assigned to the statin (n = 61, 10 mg daily) and control group (n = 59). CAC and biochemical analyses were performed at baseline and 12 months.ResultsAt baseline, CAC was observed in 30% and 21% of patients in the statin and control groups, respectively (p = 0.39). The calcium score at baseline and its absolute and relative changes over 12 months of follow up were similar among the groups. In the statin group, total cholesterol (p < 0.001), low density lipoprotein cholesterol (p < 0.001) and triglycerides (p = 0.005) decreased, and the estimated glomerular function rate increased (p<0.001) significantly. CRP levels remained stable (p = 0.52) in the statin group but increased in the control group (p = 0.01). In the multivariate model, there was no difference in CAC progression between the groups (group effect p = 0.034; time-effect p = 0.23; interaction p = 0.74). Similar results were obtained when only patients with ≥ 10AU calcium score (calcified) were analyzed (group effect p = 0.051; time-effect p = 0.58; interaction p = 0.99).ConclusionAlthough statins reduce the levels of cholesterol, triglycerides, inflammation and improve graft function, the dose adopted in the current study did not delay CAC progression within 12 months of follow up.Trial RegistrationBrazilian Clinical Trials Registry RBR-32RFMB

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Section: Discussionmentioning

confidence: 99%

Effect of Statins on the Progression of Coronary Calcification in Kidney Transplant Recipients

et al. 2016

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“…We know patients undergoing renal transplantation have better graft function on statins. ( 8 ) Statins elicit immunomodulatory effects. A tumor microenvironment rich in cholesterol with tumor‐infiltrating CD8+ T cells promotes enhanced expressions of immune checkpoint proteins and T cell exhaustion, allowing tumor cells to escape immune surveillance.…”

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confidence: 99%

Statins: A Panacea to Reduce Mortality in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma?

Shawcross

Suddle

2021

Liver Transpl

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Statin Therapy Ameliorates Renal Allograft Function

Cited by 2 publications

References 9 publications

Effect of Statins on the Progression of Coronary Calcification in Kidney Transplant Recipients

Effect of Statins on the Progression of Coronary Calcification in Kidney Transplant Recipients

Statins: A Panacea to Reduce Mortality in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma?

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