2011
DOI: 10.1016/j.jtcvs.2011.08.004
|View full text |Cite
|
Sign up to set email alerts
|

Statin therapy attenuates growth and malignant potential of human esophageal adenocarcinoma cells

Abstract: We demonstrate that treatment of human esophageal adenocarcinoma cells with simvastatin attenuates growth, by decreasing cell viability, decreasing cell proliferation, and increasing apoptosis, and attenuates metastatic potential, by decreasing expression of key metastatic markers. These findings identify simvastatin as a potential therapeutic and chemopreventive modality to thwart the progression of esophageal adenocarcinoma.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
38
0

Year Published

2012
2012
2022
2022

Publication Types

Select...
8

Relationship

0
8

Authors

Journals

citations
Cited by 48 publications
(39 citation statements)
references
References 26 publications
1
38
0
Order By: Relevance
“…Our findings are consistent with experimental studies which have demonstrated that statins promote apoptosis and limit proliferation in EAC cell lines [5][6][7][8] 6 , an adhesion molecule involved in trans-endothelial tumour cell migration and metastatic spread 23,24 . Whether these mechanisms operate to explain the associations observed in this study is not clear.…”
Section: Biological Mechanismssupporting
confidence: 92%
See 1 more Smart Citation
“…Our findings are consistent with experimental studies which have demonstrated that statins promote apoptosis and limit proliferation in EAC cell lines [5][6][7][8] 6 , an adhesion molecule involved in trans-endothelial tumour cell migration and metastatic spread 23,24 . Whether these mechanisms operate to explain the associations observed in this study is not clear.…”
Section: Biological Mechanismssupporting
confidence: 92%
“…There has been a considerable research focus on the potential anti-cancer effects of statins (3-hydroxy-3-methylglutaryl coenzyme A [HMG-CoA] reductase inhibitors), which are commonly prescribed for the primary and secondary prevention of cardiovascular disease 4 . A body of basic research has demonstrated that statins promote apoptosis and limit proliferation in EAC and ESCC cell lines [5][6][7][8] . Epidemiological investigations have demonstrated that use of statins post-diagnosis is associated with reduced risk of cancerspecific mortality in a number of malignancies, including prostate, breast and colorectal carcinoma [9][10][11] .…”
Section: Introductionmentioning
confidence: 99%
“…For example, in a recent study, Kodach and coworkers reported that simvastatin can reduce the proliferation and augment the chemosensitivity of colorectal cancer cells via the bone morphogenetic protein pathway [29]. Also, simvastatin has been found to attenuate the growth and malignant potential of human esophageal adenocarcinoma [30] and hepatic cancer cells [31], but most of these studies were restricted only to cell lines with no in vivo evidence. We observed that simvastatin Fig.…”
Section: Discussionmentioning
confidence: 99%
“…All reported anti-proliferative and pro-apoptotic effects [106][107][108] . Qresearch, a prospective study based on 24 general practice research databases from England and Wales, have shown that statins were protective against esophageal cancer development in both men and women.…”
Section: Statins and Eac Chemopreventionmentioning
confidence: 99%