Statin therapy improves serum Annexin A1 levels in patients with acute coronary syndrome

Abstract

Background: The objective of the study is to estimate the protective role of statins in patients with acute coronary syndrome (ACS) through modulation of annexin A1 (AnxA1) serum levels. Methods: A total number of 63 patients with ACS were recruited compared with 25 healthy control subjects. The enrolments were divided into – Group (A): Patients with ACS on atorvastatin ( n = 20), Group (B): Patients with ACS on rosuvastatin ( n = 20), Group (C): Patients with ACS but not on statin therapy ( n = 23), and Group (D): Healthy controls ( n = 25). Body mass index and both systolic blood pressure and diastolic blood pressures were measured. Lipid profile, atherogenic index, cardiac risk ratio, cardiovascular risk index, and human AnxA1 level were estimated. Results: AnxA1 serum level was higher in patients with ACS (3.35 ± 0.84) compared with healthy controls (1.71 ± 0.91) and nonstatin using patients (1.47 ± 0.76) ( P = 0.005). Conclusion: AnxA1 serum level is reduced in patients with ACS compared with healthy controls. Patients with ACS on statins therapy showed a higher level of AnxA1 compared with patients with ACS but not on statin therapy.

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“…18,19 ST-MI reflects a total reduction of coronary blood flow caused by complete occlusion of coronary vessels; however, NST-MI reflects a partial reduction of coronary blood flow caused by partial occlusion of coronary vessels similar to unstable angina. 20,21 Acute MI is defined according to the last fourth definition as the presence of acute MI detected by abnormal cardiac biomarkers in the setting of evidence of acute myocardial ischemia. 22 Acute MI is classified based on ST-segment elevation on the ECG and is further classified into six types: infarction due to coronary atherothrombosis (type 1), infarction due to a supplydemand mismatch that is not the result of acute atherothrombosis (type 2), infarction causing sudden death without the opportunity for biomarker or ECG confirmation (type 3), infarction related to a percutaneous coronary intervention (PCI) (type 4a), infarction related to thrombosis of a coronary stent (type 4b), and infarction related to coronary-artery bypass grafting (CABG) (type 5).…”

“…ACS is a spectrum of acute myocardial ischemia due to a sudden decrease in coronary blood flow, ranging from unstable angina to myocardial infarction (MI), which is either ST‐elevation MI (ST‐MI) to non‐ST‐elevation MI (NST‐MI) 18,19 . ST‐MI reflects a total reduction of coronary blood flow caused by complete occlusion of coronary vessels; however, NST‐MI reflects a partial reduction of coronary blood flow caused by partial occlusion of coronary vessels similar to unstable angina 20,21 . Acute MI is defined according to the last fourth definition as the presence of acute MI detected by abnormal cardiac biomarkers in the setting of evidence of acute myocardial ischemia 22 .…”