Statin use after esophageal cancer diagnosis and survival: A population based cohort study

Cardwell, Christopher; Spence, Andrew; Hughes, Carmel; Murray, Liam

doi:10.1016/j.canep.2017.04.015

Cited by 28 publications

(46 citation statements)

References 16 publications

(13 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After a review of full texts, 14 studies which met our inclusion criteria were identified and selected for data extraction and metaanalysis. 12,[17][18][19][20][21][22][23][24][25][26][27][28][29] A flow diagram depicting our literature search strategy and study selection process is shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

“…While statin users were less likely to be diagnosed with metastatic breast cancer at initial presentation in some studies, 17,19 there was no relationship between statin use and stage at diagnosis in other studies. 18,22,29…”

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

“…Additional data was reported for the commonly used lipophilic statin, simvastatin, which was associated with lower rates of cancer recurrence (2 studies, HR 0.64; 95% CI 0.49-0.84) 12,23 and a trend towards improved CSS (3 studies, HR 0.66; 95% CI 0.38-1.15) and OS (3 studies, HR 0.73; 95% CI 0.42-1.27). 18,19,23 Adequacy of follow-up…”

Section: Cancer Epidemiologymentioning

confidence: 99%

See 2 more Smart Citations

Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta‐analysis

Manthravadi

Shrestha

Madhusudhana

2016

Intl Journal of Cancer

123

107

View full text Add to dashboard Cite

Statins have shown antineoplastic properties in preclinical studies with breast cancer cells. They inhibit the enzyme "HMG CoA reductase" and the expression of this enzyme in cancer cells has been implicated as a favorable prognostic factor in patients with breast cancer. After a search of MEDLINE and Embase from inception through November 2015, 817 abstracts were reviewed to identify studies that described an association between statin use and outcomes in breast cancer. A total of 14 studies which included 75,684 women were identified. In a meta-analysis of 10 studies, statin use was associated with improved recurrence-free survival (RFS; HR 0.64; 95% CI 0.53-0.79, I2 5 44% Preclinical studies have demonstrated a direct inhibitory effect of lipophilic statins on breast cancer cells in vitro and in murine breast cancer models.5 Data from a window-ofopportunity trial in which patients received statins during the perioperative period reported similar findings and furthermore, identified a preferential effect of statins on tumors which expressed high levels of HMG CoA reductase. 6 Expression of this enzyme in breast cancer cells has previously been found to have a prognostic significance. 7A body of evidence from epidemiologic studies describes the relationship between statin use and outcomes in patients with breast cancer. We thus performed a systematic review of existing literature to better ascertain this effect. MethodsThis systematic review was conducted following guidance provided by the Cochrane Handbook and is reported according to the Meta-Analysis of Observational Studies in Epidemiology (MOOSE) guidelines. 8,9Search Strategy A systematic search of the electronic databases MEDLINE and Embase was conducted from inception through November 2015 to identify studies which described the relationship between the use of statins and survival in patients with breast cancer. Free text words and MeSH terms were used along with Boolean operators in the search (available in Online Supplementary File). The title and abstract of all studies identified in the search were reviewed by two reviewers (Sashidhar Manthravadi and Anuj Shrestha) independently to exclude studies that did not answer the research question of interest. Full texts of the remaining articles were then

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Characteristics Of Included Studiesmentioning

confidence: 99%

Section: Cancer Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta‐analysis

Manthravadi

Shrestha

Madhusudhana

2016

Intl Journal of Cancer

123

107

View full text Add to dashboard Cite

show abstract

“…Two previous studies performed meta-analyses but suffered obvious limitations in terms of an insufficient number of included studies and the lack of unified end points [8,9]. Some articles have previously shown that different statin types may have different effects on breast cancer incidence [3][4][5] and prognosis [5,[10][11][12]19]. Thus, we preformed the current meta-analysis using mortality as the unified end point; moreover, we sought to explore the different influences of statin types and different follow-up times on the prognosis of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

The relationship between statins and breast cancer prognosis varies by statin type and exposure time: a meta-analysis

Liu

Guan

et al. 2017

Breast Cancer Res Treat

102

View full text Add to dashboard Cite

Purpose Breast cancer is the most common cancer in females and the leading cause of death worldwide. The effects of statins on breast cancer prognosis have long been controversial; thus, it is important to investigate the relationship between statin type, exposure time, and breast cancer prognosis. This study sought to explore the effect of statins, as well as the different effects of statin solubility and variable follow-up times, on breast cancer prognosis.

show abstract

“…Statin use was found to be associated with increased overall DFS, in line with previous studies exploring the impact of statin use in breast cancer patients. 28,[33][34][35][36] Pre-or postdiagnosis statin studies have already shown a beneficial effect on survival 34,36 but not all of them. 28,33,35 Even in the latter case, where the studies showed no effect on survival, subgroups revealed any significant beneficial correlations; however, the number of patients in each subgroup was too small to draw definite conclusions, and the results should be interpreted with extreme caution.…”

Section: Discussionmentioning

confidence: 99%

Statins and risk of breast cancer recurrence.

Sakellakis

Kostaki

Akinosoglou

et al. 2016

JCO

View full text Add to dashboard Cite

Background:The primary end point of our study was to test whether the concurrent use of a statin is related to a lower risk of recurrence and increased relapse-free survival in patients with early breast cancer. Materials and methods:We reviewed 610 female patients with stage I, II, or III breast cancer who had been surgically treated and who had subsequently received at least adjuvant chemotherapy in order to prevent recurrence. Results: Among the 610 patients with breast cancer, 83 (13.6%) were receiving a statin on a chronic basis for other medical purposes. Overall, statin users displayed longer mean relapsefree survival (16.6 vs 10.2 years, P=0.028). After data had been adjusted for patient and disease characteristics, statin users maintained a lower risk of recurrence. This favorable outcome in statin users was particularly evident when we included only younger patients in the analysis (20 vs 10 years, P=0.006). Conclusion: Statins may be linked to a favorable outcome in early breast cancer patients, especially in younger age-groups.

show abstract

Statin use after esophageal cancer diagnosis and survival: A population based cohort study

Cited by 28 publications

References 16 publications

Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta‐analysis

Impact of statin use on cancer recurrence and mortality in breast cancer: A systematic review and meta‐analysis

The relationship between statins and breast cancer prognosis varies by statin type and exposure time: a meta-analysis

Statins and risk of breast cancer recurrence.

Contact Info

Product

Resources

About