Statin Use and 25‐Hydroxyvitamin D Blood Level Response to Vitamin D Treatment of Older Adults

Bischoff‐Ferrari, Heike A.; Fischer, Karina; Orav, E. John; Dawson‐Hughes, Bess; Meyer, Ursina; Chocano-Bedoya, Patricia; Meyer, Odile; Ernst, Rahel; Schietzel, Simeon; Eberli, Franz R.; Staehelin, Hannes B.; Freystätter, Gregor; Roas, Susanne; Egli, Andreas; Wilson, Nicholas

doi:10.1111/jgs.14784

Cited by 14 publications

(11 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Since dietary vitamin D intake from food and supplements is the main determinant of vitamin D status in older adults, increased 25(OH)D levels among statin users were particularly seen among those with inadequate vitamin D intake [21]. In addition, Bischoff-Ferrari et al in a pooled analysis of three double-blind randomized clinical trials suggested that lower 25(OH)D response to vitamin D supplementation may be a class effect of all statins, which differ according to vitamin D dosing regimens [13].…”

Section: Discussionmentioning

confidence: 99%

“…Previously, few observational studies and randomized controlled trials reported conflicting results regarding the effect of statins on 25(OH)D concentrations. Some studies described higher 25(OH)D concentrations among statin users, whereas others did not [7][8][9][10][11][12][13][14][15]. Nevertheless, these studies were limited by small sample size, subjects with acute coronary syndrome, individual generic statins, diabetics hospitalized, and postmenopausal women with osteopenia [7,9,11,[14][15].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Statins on Serum Vitamin D Concentrations Among Older Adults

Orces¹,

Montalván²,

Tettamanti³

2020

Cureus

View full text Add to dashboard Cite

Background Randomized and observational studies have previously reported inconsistent results for the direct association between statin therapy and 25, hydroxyvitamin D [25(OH)D] levels. Thus, the present study aimed to examine the relationship between statin use and 25(OH)D and its metabolites concentrations in a large nationally representative sample of older adults. Methods This study was conducted using data from the National Health and Nutrition Examination Survey. Participants were asked to show the medication containers of all the products used in the previous 30 days, and the prescription of statins was defined on the three-level nested therapeutic classification scheme of Cerner Multum's Lexicon. General linear models adjusted for potential confounders were created to compare 25(OH)D concentrations between older adults taking statins and those who did not. Results A total of 6,261 participants with a mean age of 69.5 years comprised the study sample. Of those, 40.2% were taking statins with a median length of therapy of 5 years. Adjusted mean 25(OH)D 3 and 25(OH)D levels were 3.3 and 4.4 nmol/L higher among participants taking statins than those who did not, respectively. Moreover, this association was consistently seen regardless of the duration of therapy and particularly in subjects taking simvastatin, atorvastatin, or rosuvastatin. In subgroup analyses according to BMI categories and vitamin D intake, higher 25(OH)D levels were also seen among statin users. By contrast, this association was attenuated among those with a daily vitamin D between 400 and 800 and >800 IU. Conclusion Older adults on statin therapy had significantly higher serum 25(OH)D concentrations. Additional research should be conducted to define the mechanism of this association and determine if the pleiotropic effects attributed to statins may be mediated by vitamin D.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Statins on Serum Vitamin D Concentrations Among Older Adults

Orces¹,

Montalván²,

Tettamanti³

2020

Cureus

View full text Add to dashboard Cite

show abstract

“…Numerous medications can lead to low bone mineral density and an increased risk for fracture. Statins may cause a decline in vitamin D levels and lead to smaller increases in serum 25(OH)D concentration even with supplementation [ 18 , 19 ]. Anticonvulsant medications accelerate vitamin D metabolism and increase the risk for fracture [ 65 ].…”

Section: Life In the Margins: The Health Impact Of Micronutrient Insumentioning

confidence: 99%

Healthy ageing: the natural consequences of good nutrition—a conference report

et al. 2018

View full text Add to dashboard Cite

Many countries are witnessing a marked increase in longevity and with this increased lifespan and the desire for healthy ageing, many, however, suffer from the opposite including mental and physical deterioration, lost productivity and quality of life, and increased medical costs. While adequate nutrition is fundamental for good health, it remains unclear what impact various dietary interventions may have on prolonging good quality of life. Studies which span age, geography and income all suggest that access to quality foods, host immunity and response to inflammation/infections, impaired senses (i.e., sight, taste, smell) or mobility are all factors which can limit intake or increase the body’s need for specific micronutrients. New clinical studies of healthy ageing are needed and quantitative biomarkers are an essential component, particularly tools which can measure improvements in physiological integrity throughout life, thought to be a primary contributor to a long and productive life (a healthy “lifespan”). A framework for progress has recently been proposed in a WHO report which takes a broad, person-centered focus on healthy ageing, emphasizing the need to better understand an individual’s intrinsic capacity, their functional abilities at various life stages, and the impact by mental, and physical health, and the environments they inhabit.

show abstract

“…[58] Only one study claimed that statin decreased vitamin D levels by 21.4% in patients aged 60 and older. [59] So far, evidence regarding the association of statin and vitamin D has remained inconclusive due limited data and conflicting results. Further randomized controlled trials are warranted to make a direct correlation.…”

Section: Cholesterol Statin and Brain Diseasementioning

confidence: 99%