Statin use and pneumonia risk in Parkinson's disease

Yun, Seo Jung; Byun, Seong Jun; Kim, Han Joon; Oh, Byung Mo; Lee, Da Yun; Park, Sang Jun; Seo, Han Gil

doi:10.1016/j.parkreldis.2021.09.021

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…24 The possible mechanism that has been suggested is that cholesterol is required for the absorption and transport of certain bacteria and by reducing the cholesterol levels statins lead to a reduction in bacterial entry, propagation, and destruction of lung tissue. 23,25 A previous study evaluating the risk of infections and statin use reported a significant reduction in infections, however, it failed to demonstrate a significant correlation between any particular type of infection. 5 Considering that the study included only 1934 patients of which 1248 received a statin it is possible that it was underpowered to detect a relationship with respiratory infections.…”

Section: Discussionmentioning

confidence: 96%

“…Another study carried out on patients admitted with myocardial infarction reported a reduced risk of pneumonia 24 . The possible mechanism that has been suggested is that cholesterol is required for the absorption and transport of certain bacteria and by reducing the cholesterol levels statins lead to a reduction in bacterial entry, propagation, and destruction of lung tissue 23,25 …”

Section: Discussionmentioning

confidence: 99%

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Effect of preoperative statins on respiratory complications after coronary artery bypass grafting

Narayan

Swamy

Ghorai

et al. 2022

Journal of Cardiac Surgery

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Objectives Limited data exist on the effect of preoperative statin therapy on postoperative respiratory complications. Machine learning algorithms (MLA) can process large, heterogenous data, and have immensely improved the ability for risk prediction. In this study, we sought to examine the role of preoperative statins on respiratory complications in patients undergoing coronary artery bypass grafting (CABG) using MLA. Methods The study population contained the data of patients who underwent CABG between the years 2015 and 2019 (n = 5638). Three hundred and thirty‐seven independent variables were recorded and the data was randomly split with stratified sampling into training and testing data with 20% of the data (1113 records) reserved for model testing. Various models including linear models, Random forest, SVM, and XGboost were trained to predict the incidence of postoperative respiratory complications. Forty‐seven important features were found to impact model prediction (p ≤ .05) using the global surrogate model method. A conventional multivariable linear regression model was then used to identify predictors of respiratory complications. Results One thousand three hundred sixty‐two (24.5%) patients developed a respiratory complication in our series. The respiratory complication was seen in 561 (29.7%) of the patients who were not on statin compared to only 801 (21.8%) who were on a statin, p < .0001. The area under the curve for receiver operating characteristic curve using statins and respiratory complications was 0.706. Statins showed positive feature importance in all the MLA models. Conclusions MLA showed that statins impacted the prediction of respiratory complications in all the models studied. The study confirmed that preoperative statins reduced the risk of respiratory complications by 21%.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Effect of preoperative statins on respiratory complications after coronary artery bypass grafting

Narayan

Swamy

Ghorai

et al. 2022

Journal of Cardiac Surgery

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Enhancing the human health and lifespan: a targeted strategy emphasizing statins

Calabrese,

Pressman

2024

Biogerontology

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Possible link between statin and iron deficiency anemia: A South Korean nationwide population-based cohort study

Ahn,

Lee,

Won

2023

Sci. Adv.

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An extensive evaluation of disease occurrence after statin use based on a “hypothesis-free” approach remains scarce. To examine the effect of statin use on the potential risk of developing diseases, a propensity score–matched cohort study was executed using data from the National Sample Cohort in South Korea. A total of 7847 statin users and 39,235 nonstatin users were included in the final analysis. The period of statin use was defined as our main time-dependent exposure and was divided into three periods: current, recent, and past. The main outcomes were defined as new-onset diseases with ≥100 events based on the International Statistical Classification of Diseases, 10th Revision. We calculated the adjusted hazard ratios and 95% confidence intervals (CIs) using Cox regression. We found that statin use significantly increased the risk of developing iron deficiency anemia up to 5.04 times (95% CI, 2.11 to 12.03). Therefore, the iron levels of patients using statins should be monitored carefully.

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Statin use and pneumonia risk in Parkinson's disease

Cited by 4 publications

References 12 publications

Effect of preoperative statins on respiratory complications after coronary artery bypass grafting

Effect of preoperative statins on respiratory complications after coronary artery bypass grafting

Enhancing the human health and lifespan: a targeted strategy emphasizing statins

Possible link between statin and iron deficiency anemia: A South Korean nationwide population-based cohort study

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