Statin Use before By-Pass Surgery Decreases the Incidence and Shortens the Duration of Postoperative Atrial Fibrillation

Özaydın, Mehmet; Doğan, Abdullah; Varol, Ercan; Kapan, Sahin; Tüzün, Nurullah; Peker, Oktay; Aslan, Şükrü; Altınbaş, Ahmet; Öcal, Ahmet; İbrişim, Erdoǧan

doi:10.1159/000094589

Cited by 92 publications

(59 citation statements)

References 33 publications

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“…Regarding the effects of ACE inhibitors or AT 1 -blockers in the prevention of postsurgery AF, no randomized studies have been published. Finally, it has been suggested that POAF was less frequent and its duration shorter in patients treated with statins in comparison with a nonstatin group, 56,57 and associated with a decrease in inflammatory markers.…”

mentioning

confidence: 99%

Atrial Fibrillation After Cardiac Surgery: Incidence, Risk Factors, and Economic Burden

Rostagno

Meir

Gelsomino

et al. 2010

Journal of Cardiothoracic and Vascular Anesthesia

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Objective: To evaluate the incidence of postoperative atrial fibrillation (POAF), the predisposing factors, the results of treatment before discharge, and the impact on duration and costs of hospitalization.Design: A prospective observational study. Conclusions: The overall incidence of POAF in the authors' center is close to 30%; 95.3% of patients were discharged in sinus rhythm. The increase in length and costs of hospitalization (on average, 1.0 day with a burden of about €1,800/ patient) were significantly lower than in previous investigations. Methods

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mentioning

confidence: 99%

Atrial Fibrillation After Cardiac Surgery: Incidence, Risk Factors, and Economic Burden

Rostagno

Meir

Gelsomino

et al. 2010

Journal of Cardiothoracic and Vascular Anesthesia

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“…Both cardiac surgery and heart failure activate RAS (17) which in turn may induce electrical and structural remodeling (8,16). Structural and electrical remodeling may initiate and perpetuate postoperative AF (18). Aldosterone has parasympathetic (19,20) and sympathetic (15) effects, both of which may cause AF (21).…”

Section: Discussionmentioning

confidence: 99%

Association between renin-angiotensin-aldosterone system blockers and postoperative atrial fibrillation in patients with mild and moderate left ventricular dysfunction

Özaydın

Varol²,

Türker³

et al. 2010

Anadolu Kardiyol Derg

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Association between renin-angiotensin-aldosterone system blockers and postoperative atrial fibrillation in patients with mild and moderate left ventricular dysfunctionHafif ve orta derecede sol ventrikül disfonksiyonu olan hastalarda renin-anjiyotensinaldosteron sistem blokerleri ile kalp cerrahisi sonrası gelişen atrial fibrilasyon arasındaki ilişki ABS TRACTObjective: The aim of the study was to evaluate the association between renin -angiotensin -aldosterone system blockers and risk of postoperative atrial fibrillation (AF) development in patients with mild and moderate left ventricular systolic dysfunction. Methods: The population of this prospective and observational study consisted of 269 patients with an ejection fraction of ≤ 50% undergoing coronary artery bypass and/or valve surgery. Use of renin -angiotensin-aldosterone system blockers (angiotensin converting enzyme inhibitors (ACEI), angiotensin receptor blockers (ARB) and spironolactone) and their association with postoperative AF (AF episode lasting > 5 min) were evaluated. In statistical analysis t test for independent samples, Chi-square test and Mann Whitney U test were used for comparison of variables between groups. Predictors of postoperative AF were determined by multiple logistic regression analysis.

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“…Statins, which have anti-inflammatory actions, have been shown to be effective in preventing AF in different patient populations (4)(5)(6)(7)(8)(9), including recurrence of AF after electrical cardioversion (EC) (10,11). N-3 polyunsaturated fatty acids (PUFAs) also have anti-inflammatory actions (12).…”

Section: Introductionmentioning

confidence: 99%

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study

Özaydın¹,

Erdoğan²,

Tayyar³

et al. 2011

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N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study N-3 çoklu doymamış yağ asitlerinin kullanımı elektriksel kardiyoversiyon sonrası inflamasyon ve atriyal fibrilasyon nüks oranlarını azaltmaz: Prospektif randomize bir çalışma ÖZETAmaç: Bu prospektif randomize çalışmanın amacı, n-3 çoklu doymamış yağ asitlerinin elektriksel kardiyoversiyon sonrası atriyal fibrilasyon (AF) nüksü üzerine olan etkilerini araştırmaktır.Yöntemler: Gerekli hasta sayısı, sinüs ritmi idamesinin amiyodaron grubunda %20, yağ asidi grubunda %65 olacağı tahmin edilerek hesaplandı. Alfa değeri 0.05 ve güç %80 olacak şekilde anlamlı sonuç elde etmek için her bir grupta 22 hastanın gerekli olduğu bulundu. Toplam 47 hasta elektriksel kardiyoversiyon öncesi amiyodaron (n=24) ve amiyodaron+n-3 çoklu doymamış yağ asidi (n=23) gruplarına randomize edildiler. Sonlanım noktası 12 aylık takipte AF nüksü olarak belirlendi. N-3 çoklu doymamış yağ asitlerinin inflamasyon üzerine olan etkisi C-reaktif protein düzeylerinin ölçülmesi ile değerlendirildi. İstatistiksel analiz eşleştirilmemiş Student t-testi, Mann-Whitney U testi Ki-kare testi ile yapıldı. Atriyal fibrilasyon nüksü, potansiyel etkili faktörleri kontrol ederek Cox oransal regresyon modeli ile değerlendirildi. Bulgular: Amiyodaron grubundaki 9 hastada (%37.5) ve amiyodaron+n-3 çoklu doymamış yağ asidi grubundaki 9 hastada (%39.1) nüks gözlendi (p=1). Cox regresyon analizinde, nüks için risk faktörleri önceden elektriksel kardiyoversiyon yapılmış olması (izafi risk 10.33; %95 GA 1.74-61.10; ABSTRACTObjective: The purpose of the present prospective randomized study was to evaluate the effects of n-3 polyunsaturated fatty acids on recurrence rates of atrial fibrillation (AF) and inflammation after electrical cardioversion. Methods: Calculation of the number of patients needed was based on the assumption of 20% and 65% chance of maintaining sinus rhythm with amiodarone and with polyunsaturated fatty acids, respectively. To observe a significant difference with an alpha level of 0.05 and a power of 0.80 it was necessary to include 22 patients in each group. A total of 47 patients were randomized to amiodarone (n=24) and amiodarone plus n-3 polyunsaturated fatty acids (n=23) groups before scheduled electrical cardioversion. The end-point was the recurrence of AF during 12-month follow-up. Effect of n-3 polyunsaturated fatty acids on inflammation was evaluated with high sensitivity C-reactive protein level measurements. Statistical analysis was performed using unpaired Student' t, Mann Whitney U and Chi-square tests. We analyzed the recurrence of AF using the Cox proportional hazards regression model to control for potentially confounding factors. Results: Nine patients in the amiodarone group (37.5%), and 9 patients in the amiodarone plus n-3 polyunsaturated fatty acids group (39.1%) had recurrence of AF during follow-up (p=1). With the Cox proportional model, risk f...

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Statin Use before By-Pass Surgery Decreases the Incidence and Shortens the Duration of Postoperative Atrial Fibrillation

Cited by 92 publications

References 33 publications

Atrial Fibrillation After Cardiac Surgery: Incidence, Risk Factors, and Economic Burden

Atrial Fibrillation After Cardiac Surgery: Incidence, Risk Factors, and Economic Burden

Association between renin-angiotensin-aldosterone system blockers and postoperative atrial fibrillation in patients with mild and moderate left ventricular dysfunction

N-3 polyunsaturated fatty acids administration does not reduce the recurrence rates of atrial fibrillation and inflammation after electrical cardioversion: a prospective randomized study

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