Statin use in patients with type 2 diabetes has lower risk of hip fractures: A Taiwan national population‐based study

Abstract

Aims Type 2 diabetes mellitus (T2DM) frequently co‐exists with osteoporosis and dyslipidemia. Statins have been commonly used in the treatment of dyslipidemia. Recent studies have indicated a therapeutic role of statins in decreasing the risk of osteoporosis and fractures, but conflicting results have been reported. This study investigated the association between statin use and hip fracture (HFx) risk among T2DM patients. Materials and Methods A retrospective Taiwan population‐based propensity‐matched cohort study was performed using the Diabetes Mellitus Health Database from Taiwan National Health Insurance Research Database. Patients with newly diagnosed with T2DM between 2010 and 2014 were identified. Patients who previously used statins and had ever suffered HFx before the index date were excluded. HFx that occurred from 2010 to 2019 was collected to compute the cumulative rate of HFx. Hazard ratios (HRs) were calculated for the HFx risk according to the use or non‐use of statins. To evaluate the dose–effect relationship of statins, sensitivity analyses were conducted. Results After propensity score matching for age and sex, 188,588 patients were identified as statin users and non‐statin users. Statin use after T2DM diagnosis was associated with a decreased HFx risk with an adjusted HR (aHR) of 0.69 (P < 0.001). A dose–effect relationship was identified. The aHRs for developing HFx were 1.29, 0.67, and 0.36 for patients who used 28–174, 175–447, and >447 cumulative defined daily doses of statins, respectively (P < 0.001). Conclusions Statin use in adults with T2DM showed a lower risk of HFx by demonstrating a dose–response relationship.

The Effect of Statin Therapy on Bone Metabolism Markers and Mineral Density: Aa GRADE-Assessed Systematic Review and Dose-Response Meta-Analysis of Randomized Controlled Trials

“…31 . Another recently published study has shown that treatment with statins in adults with type 2 diabetes mellitus was associated with a lower risk of hip fractures demonstrating a dose-response relationship 32 .…”

Letter: Statin use in patients with type 2 diabetes has lower risk of hip fractures

“…We read with great interest the article 'Statin use in patients with type 2 diabetes has lower risk of hip fractures: A Taiwan national population-based study' by Tien-Ching Lee et al 1 They described that statin use was a significant and independent protective factor of hip fractures with an adjusted HR of 0.69. In addition, they noted a significant dose-response relationship between statin use and hip fracture risk.…”