2018
DOI: 10.2174/1381612823666170913170527
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Statins and Contrast-Induced Nephropathy: A Systematic Review and Meta-Analysis

Abstract: Contrast-induced nephropathy (CIN) is a type of acute kidney injury associated with intravascular administration of iodinated contrast, usually reversible. Contrast agents are an essential component of invasive and noninvasive coronary angiography. These agents have been modified over time to enhance patient safety and tolerability, but adverse reactions still occur. CIN has been variably defined, as a rise in serum creatinine of 0.5 mg/dl, or a 25% increase in serum creatinine above baseline within 24-72 hour… Show more

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Cited by 11 publications
(7 citation statements)
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“…The ROC curves show that the sensitivity and specificity of serum and urine NGAL are relatively high. According to multiple systematic reviews, the NGAL level in the serum or urine possesses fairly high specificity and sensitivity in the early diagnosis of CIN [4]. The NGAL level starts to rise at 6 h after interventional operations in the CIN group compared with that in the control group.…”
Section: Discussionmentioning
confidence: 99%
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“…The ROC curves show that the sensitivity and specificity of serum and urine NGAL are relatively high. According to multiple systematic reviews, the NGAL level in the serum or urine possesses fairly high specificity and sensitivity in the early diagnosis of CIN [4]. The NGAL level starts to rise at 6 h after interventional operations in the CIN group compared with that in the control group.…”
Section: Discussionmentioning
confidence: 99%
“…With the current rapid development of medical science, interventional techniques have been extensively applied to diagnose and treat diseases, and this has led to increased numbers of contrast-induced nephropathy (CIN) cases [1–3]. Studies have shown that acute kidney injury (AKI) triggered by CIN accounts for 11% of the total cases, becoming the third most important cause of iatrogenic AKI [4]. Currently, clinically significant damage is defined as impairment of renal function occurring within 48 h after administration of contrast media, manifested by an absolute increase in the serum creatinine (SCr) level of at least 44 umol/L or by a relative increase of at least 25% over the baseline value in the absence of another cause.…”
Section: Introductionmentioning
confidence: 99%
“… 5 , 7 It is noteworthy that the elevated preprocedural concentration of the high-sensitivity CRP was found to increase the risk of CIN in patients who had underwent PCI. 18 …”
Section: Discussionmentioning
confidence: 99%
“…According to findings lack of attention to maintenance of oral contrast material surplus in good condition, Failure to educate patients about the intern to the usual diet and High fluid intake after completion of the test was the weakest observed safety rules in the centers regarding non-inject able administration of contrast material to patients ( 26 ). Nevertheless, preparation, administration and maintenance of non-inject able contrast agents in health and a suitable environment, in prevention of transmission of infectious agents to patients and the incidence of adverse events prescribing this class of contrast agents is absolutely crucial ( 27 ).…”
Section: Discussionmentioning
confidence: 99%