Statins and coronary artery calcium: What's the score?

German, Charles; Shapiro, Michael D.

doi:10.1016/j.atherosclerosis.2020.11.014

Cited by 5 publications

(2 citation statements)

References 16 publications

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“…Kaplan-Meier analyses using fully adjusted models were estimated to visualize the event-free survival among participants. Given data that suggest statin use increases CAC (18,19), a sensitivity analysis was conducted to evaluate associations after additionally adjusting for statin use. Exploratory analyses using Cox models stratified by sex and race/ethnicity were also generated, excluding adjustment for sex and race/ethnicity in their respective models.…”

Section: Methodsmentioning

confidence: 99%

Physical Activity, Coronary Artery Calcium, and Cardiovascular Outcomes in the Multi-Ethnic Study of Atherosclerosis (MESA)

German

Fanning

Singleton

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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Introduction: Although the inverse relationship between physical activity (PA) and cardiovascular disease (CVD) is well established, observational studies suggest that very high levels of PA may be harmful. This study sought to understand the relationship between PA, coronary artery calcium (CAC), and cardiovascular outcomes among individuals at different levels of risk. Methods: PA and CAC were assessed in 6777 baseline participants of the Multi-Ethnic Study of Atherosclerosis. Total PA in METminutes per week was categorized into quartiles, and CAC was categorized as "low risk" (<100 Agatston units; n = 5180) and "high risk" (≥100 Agatston units; n = 1597). Cox proportional hazard regression analyses and Kaplan-Meier curves were generated to understand relationships between PA and CAC with CVD and all-cause mortality. Results: In low-risk participants in the highest PA quartile, there was a decrease in the adjusted hazard ratio (HR) for CVD (HR, 0.72; 95% confidence interval (CI), 0.56-0.94) and all-cause mortality (HR, 0.69; 95% CI, 0.57-0.84) compared with those in the lowest PA quartile. In high-risk participants in the highest PA quartile, there was a decrease in the adjusted HR for all-cause mortality (HR, 0.59; 95% CI, 0.47-0.74) compared with those in the lowest PA quartile. High PA was not associated with an increased risk of either outcome, regardless of CAC category, sex, or race/ethnicity. Conclusions: Our research suggests that there is no increased risk associated with high levels of PA, even among individuals at high risk of CVD.

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Section: Methodsmentioning

confidence: 99%

Physical Activity, Coronary Artery Calcium, and Cardiovascular Outcomes in the Multi-Ethnic Study of Atherosclerosis (MESA)

German

Fanning

Singleton

et al. 2021

Medicine &Amp; Science in Sports &Amp; Exercise

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View full text Add to dashboard Cite

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“…Recent research has shed light on the appropriate age to consider CAC testing [80] , and on the appropriate time interval for repeat CAC testing when initial CAC=0, known as the “warranty period” [81] , thereby enhancing the utility in CAC in clinical practice. Notably, statins increase CAC density [82] , thereby increasing the CAC score. Thus, the guidelines do not recommend obtaining CAC among individuals already on statin therapy [20] .…”

Section: Risk Assessment and Atherosclerosis Imagingmentioning

confidence: 99%