Statins and muscle pain

Pergolizzi, Joseph V.; Coluzzi, Flaminia; Colucci, Robert D.; Olsson, Hanna; LeQuang, Jo Ann; Al-Saadi, Jonathan; Magnusson, Peter

doi:10.1080/17512433.2020.1734451

Cited by 29 publications

(36 citation statements)

References 118 publications

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“…An exchange of statins may be beneficial, although all statins have been associated with muscle pain. In some patients, a reduction of dose is worth trying, especially in primary prevention [ 54 ]. Statins have been linked also to digestive problems, mental fuzziness, and glucose metabolism, and they may rarely cause liver damage.…”

Section: Resultsmentioning

confidence: 99%

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

et al. 2021

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Background The spread of false medical information on the web is rapidly accelerating. Establishing the credibility of web-based medical information has become a pressing necessity. Machine learning offers a solution that, when properly deployed, can be an effective tool in fighting medical misinformation on the web. Objective The aim of this study is to present a comprehensive framework for designing and curating machine learning training data sets for web-based medical information credibility assessment. We show how to construct the annotation process. Our main objective is to support researchers from the medical and computer science communities. We offer guidelines on the preparation of data sets for machine learning models that can fight medical misinformation. Methods We begin by providing the annotation protocol for medical experts involved in medical sentence credibility evaluation. The protocol is based on a qualitative study of our experimental data. To address the problem of insufficient initial labels, we propose a preprocessing pipeline for the batch of sentences to be assessed. It consists of representation learning, clustering, and reranking. We call this process active annotation. Results We collected more than 10,000 annotations of statements related to selected medical subjects (psychiatry, cholesterol, autism, antibiotics, vaccines, steroids, birth methods, and food allergy testing) for less than US $7000 by employing 9 highly qualified annotators (certified medical professionals), and we release this data set to the general public. We developed an active annotation framework for more efficient annotation of noncredible medical statements. The application of qualitative analysis resulted in a better annotation protocol for our future efforts in data set creation. Conclusions The results of the qualitative analysis support our claims of the efficacy of the presented method.

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Section: Resultsmentioning

confidence: 99%

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

et al. 2021

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“…Statins are a widely effective pharmacological therapy for treating hypercholesterolemia and preventing cardiovascular events, prescribed mainly due to their safety profile ( 27 ). There are currently seven types of statins approved by the U.S. Food and Drug Administration (FDA): atorvastatin, fluvastatin, lovastatin, pitavastatin, pravastatin, rosuvastatin, and simvastatin ( 28 ). Except for pravastatin, statins are metabolized by the cytochrome P450 pathway, transforming lipophilic compounds into hydrophobic in the liver for excretion ( 29 , 30 ).…”

Section: Facets Of Statin Therapy In Nhopimentioning

confidence: 99%

Challenging Aspects to Precise Health Strategies in Native Hawaiian and Other Pacific Islanders Using Statins

Watanabe

Seale

2022

Front. Public Health

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Cardiometabolic disorders (CD), including cardiovascular disease (CVD), diabetes, and obesity, are the leading cause of health concern in the United States (U.S.), disproportionately affecting indigenous populations such a Native Hawaiian and Other Pacific Islanders (NHOPI). Dyslipidemia, a prevalent risk factor for the development and progression of CVD, is more prone to occur in NHOPI than other populations in the U.S. High-intensity statin therapy to reduce low-density lipoprotein cholesterol is associated with the prevention of CVD events. However, significant side-effects, such as muscle disorders, have been associated with its use. Different ethnic groups could experience variation in the prevalence of statin side effects due to sociodemographic, behavioral, and/or biological factors. Therefore, identifying the most impactful determinants that can be modified to prevent or reduce statin side effects for individuals from high-risk ethnic minority groups, such as NHOPI, can lead to more effective strategies to reduce health disparities. Thus, our Mini-Review explores the challenging aspects of public health precise strategies in NHOPI taking statins, including a culturally informed additional therapy that could positively impact the NHOPI population.

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“…Currently, there are still limited therapies for IS, either by surgical intervention to remove the thrombus via thrombectomy (Yoo and Andersson, 2017) or pharmacological interventions using recombinant tissue plasminogen activator (rtPA) intravenous (IV) and lipidlowering drugs such as statins (Fuentes et al, 2009;Kazley et al, 2013;Alakbarzade and Pereira, 2020;Barthels and Das, 2020;Wechsler, 2020;Orset et al, 2021). These therapies have limited efficacy (Singh and Singh, 2019), low prognosis, and are associated with adverse reactions and the risk of complications (Zheng et al, 2019;Cui et al, 2020;Pergolizzi Jr et al, 2020). In addition, IS patients often have limited access to rtPA (Barthels and Das, 2020) due to the narrow therapeutic window (which must be administered within 4.5 h of IS onset) (Fukuta et al, 2017;Barthels and Das, 2020).…”

Section: Introductionmentioning

confidence: 99%

Crocins for Ischemic Stroke: A Review of Current Evidence

et al. 2022

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Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and well-tolerated. Pharmacokinetic studies indicate that CR has poor bioavailability and needs to convert to crocetin (CC) in order to cross the blood-brain barrier. Clinical studies have shown the efficacy of saffron and CR in treating various conditions, including metabolic syndrome, depression, Alzheimer’s disease, and coronary artery disease. There is evidence supporting CR as a treatment for ischemic stroke, although further studies are needed to confirm their efficacy and safety in clinical settings.

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Statins and muscle pain

Cited by 29 publications

References 118 publications

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

Active Annotation in Evaluating the Credibility of Web-Based Medical Information: Guidelines for Creating Training Data Sets for Machine Learning

Challenging Aspects to Precise Health Strategies in Native Hawaiian and Other Pacific Islanders Using Statins

Crocins for Ischemic Stroke: A Review of Current Evidence

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