Statins and Peripheral Arterial Disease: Potential Mechanisms and Clinical Benefits

Do Different Vascular Risk Factors Affect All Arteries Equally?

“…42,43 Routine lipid-lowering therapy (eg, with statins) in patients with PAD may reduce vascular events, cardiac morbidity, and mortality in this high-risk group. 44,45 Statin use in patients with PAD is also associated with an improvement in renal function 46 and carotid artery intima-media thickness. 47 Despite this, there is evidence showing that management of lipid levels and overall cardiovascular risk reduction in these patients is often suboptimal.…”

Screening for peripheral artery disease in dialysis patients: an opportunity for early disease detection and timely initiation of appropriate therapeutic measures

“…statins and antiplatelet agents). Statins not only improve renal function [18,19] but also reduce the high cardiovascular mortality and morbidity rates seen in those individuals [20].…”

Screening for Peripheral Arterial Disease Using the Ankle-Brachial Index in Diabetic and Other High-Risk Patients

“…9,10 Impaired renal function also negatively affects survival, limb salvage, and graft patency rates after lower extremity revascularization procedures. 9,10 Furthermore, atherosclerotic renal artery stenosis (ARAS) often coexists with PAD and is an independent predictor of long-term mortality. 11 Uncontrolled hypertension and a low ABI may provide a clue that ARAS is present.…”