Statins are Associated with a Reduced Infrarenal Abdominal Aortic Aneurysm Growth

Schouten, Olaf; Laanen, Jorinde H.H. van; Boersma, Eric; Vidaković, Radosav; Feringa, Harm H.H.; Dunkelgrün, Martin; Bax, Jeroen J.; Koning, Jan de; Urk, Hero van; Poldermans, Don

doi:10.1016/j.ejvs.2005.12.024

Cited by 241 publications

(204 citation statements)

References 38 publications

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“…Some studies used CT as well as US. 22,29,33 Most of these studies included aortic diameters from 30 mm (at baseline), except three studies, which reported from either 25 mm 31,35 or 28 mm. 13 Not all studies restricted their reporting to the aneurysm diameter range of interest (3.0-5.5 cm) and in some instances substudies were identified, which reported on a more restricted range.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Of these, 10 were prospective studies 13,22,[34][35][36][37][38][39][40][41] (including three randomised trials), four included both retrospective and prospective data 29,30,32,33 and one study reported only retrospective data. 31 Aneurysm growth was the primary outcome measure in 10 of the 15 studies. Overall, there were 7630 persons included in these 15 studies (although the two Spanish studies 32,33 may have included some duplicated patients).…”

Section: Study Characteristicsmentioning

confidence: 99%

“…The publication dates of the 15 potentially eligible studies 13,22,[29][30][31][32][33][34][35][36][37][38][39][40][41] ranged from 1994 to 2009, with patient recruitment from 1976 to 2005. Of these, 10 were prospective studies 13,22,[34][35][36][37][38][39][40][41] (including three randomised trials), four included both retrospective and prospective data 29,30,32,33 and one study reported only retrospective data.…”

Section: Study Characteristicsmentioning

confidence: 99%

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Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

Thompson

Brown²,

Sweeting³

et al. 2013

Health Technology Assessment

186

177

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This report should be referenced as follows:Thompson SG, Brown LC, Sweeting MJ, Bown MJ, Kim LG, Glover MJ, et al. Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness. Health Technol Assess 2013;17(41). Health Technology Assessment is indexed in MEDLINE, CINAHL, EMBASE, The Cochrane Library and the ISI Science Citation Index and is assessed for inclusion in the Database of Abstracts of Reviews of Effects. Health Technology Assessment is indexed and abstracted inThis journal is a member of and subscribes to the principles of the Committee on Publication Ethics (COPE) (www.publicationethics.org/).Editorial contact: nihredit@southampton.ac.ukThe full HTA archive is freely available to view online at www.journalslibrary.nihr.ac.uk/hta. Print-on-demand copies can be purchased from the report pages of the NIHR Journals Library website: www.journalslibrary.nihr.ac.uk Criteria for inclusion in the Health Technology Assessment journalReports are published in Health Technology Assessment (HTA) if (1) they have resulted from work for the HTA programme, and (2) they are of a sufficiently high scientific quality as assessed by the reviewers and editors.Reviews in Health Technology Assessment are termed 'systematic' when the account of the search appraisal and synthesis methods (to minimise biases and random errors) would, in theory, permit the replication of the review by others. HTA programmeThe HTA programme, part of the National Institute for Health Research (NIHR), was set up in 1993. It produces high-quality research information on the effectiveness, costs and broader impact of health technologies for those who use, manage and provide care in the NHS. 'Health technologies' are broadly defined as all interventions used to promote health, prevent and treat disease, and improve rehabilitation and long-term care.The journal is indexed in NHS Evidence via its abstracts included in MEDLINE and its Technology Assessment Reports inform National Institute for Health and Care Excellence (NICE) guidance. HTA research is also an important source of evidence for National Screening Committee (NSC) policy decisions.For more information about the HTA programme please visit the website: www.hta.ac.uk/ This reportThe research reported in this issue of the journal was funded by the HTA programme as project number 08/30/02. The contractual start date was in November 2009. The draft report began editorial review in July 2012 and was accepted for publication in November 2012. The authors have been wholly responsible for all data collection, analysis and interpretation, and for writing up their work. The HTA editors and publisher have tried to ensure the accuracy of the authors' report and would like to thank the reviewers for their constructive comments on the draft document. However, they do not accept liability for damages or losses arising from material published in this report.This report presents independent research...

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

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Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

Thompson

Brown²,

Sweeting³

et al. 2013

Health Technology Assessment

186

177

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“…Furthermore, a meta-analysis by Li et al [17] of six epidemiological studies also showed that respiratory disease was a risk factor for AAA (OR, 1.36; 95% CI, 1.19 to 1.55). However, the eight currently available studies [15,[28][29][30][31][32][33][34]] demonstrated a lack of association between COPD with AAA growth. These fi ndings, including the results of the present review (the same comorbidity is positively associated with AAA presence but not or even negatively associated with AAA growth), suggest that accelerated mechanisms regarding the expansion of an existing AAA may be diff erent from those regarding the initial formation of an AAA.…”

Section: Discussionmentioning

confidence: 99%

The association between body mass index and abdominal aortic aneurysm growth: a systematic review

Takagi

Umemoto

2016

Vasa

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Summary: Diabetes, a state of relative insulin resistance, is negatively associated with both the presence and growth abdominal aortic aneurysms (AAA), which could suggest a protective role of obesity against AAA presence or growth. A recent meta-analysis demonstrated a trend toward a positive, though statistically non-signifi cant, association between body mass index (BMI) and the presence of AAA. With respect to the association between obesity and AAA growth, however, the evidence had been very limited. To determine whether obesity (or BMI) is associated with AAA growth, we reviewed currently available studies with a systematic literature search. Our comprehensive search identifi ed seven eligible studies reporting the association of BMI and AAA growth rates, which included data on a total of 3,768 AAA patients. All seven identifi ed studies demonstrated no association between BMI and AAA growth. Despite a trend toward a positive association between BMI and AAA presence, the reason why BMI is not associated with AAA growth (suggested in the present review) is unclear. A discrepancy between associated comorbidities (coronary artery disease, peripheral artery disease, and chronic obstructive pulmonary disease) and AAA presence and between the same comorbidities and AAA growth, however, could be identifi ed. Further investigations are required to elucidate why BMI is not associated with AAA growth despite the trend for a positive association with AAA presence.

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“…In addition, an observational study including 130 patients follow up for 2 years, no aneurysm expansion was observed in 75 patients taking statins (Baxter et al,2008). Other studies have been also suggested that the aneurysm expansion rate was decreased in the patients who were taking statins compared with those not taking statins (Schouten et al,2006). Another important query is about the molecular pathways by which statins may affect AAA growth.…”

Section: Statinsmentioning

confidence: 99%

Actual Pharmacological Treatment to Reduce Growth of Small Abdominal Aneurysm

Ducajú¹,

Modrego²,

Farré³

et al. 2011

Diagnosis, Screening and Treatment of Abdominal, Thoracoabdominal and Thoracic Aortic Aneurysms

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Statins are Associated with a Reduced Infrarenal Abdominal Aortic Aneurysm Growth

Abstract: Statins appear to be associated with attenuation of AAA growth, irrespective of other known factors influencing aneurysm growth.

Cited by 241 publications

References 38 publications

Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

Systematic review and meta-analysis of the growth and rupture rates of small abdominal aortic aneurysms: implications for surveillance intervals and their cost-effectiveness

The association between body mass index and abdominal aortic aneurysm growth: a systematic review

Actual Pharmacological Treatment to Reduce Growth of Small Abdominal Aneurysm

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