Statins are not associated with short-term improved aneurysm healing in a rabbit model of unruptured aneurysms

Brinjikji, Waleed; Hong, Ding; Dai, Daying; Schroeder, Dana; Kallmes, David F.; Kadirvel, Ramanathan

doi:10.1136/neurintsurg-2016-012265

Cited by 9 publications

(6 citation statements)

References 23 publications

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“…[29] In a systematic review and meta-analysis of 102 studies describing 144 risk factors, there was strong evidence for the morphological factors, including size ratio, to increase rupture risk. [30] The results of our univariate model indicated that an aSR ≥3 is a factor associated with RIA. Despite the lack of significant results in the multivariate model, the RF model indicates that after the IA location, the aSR is one of the most informative variables in predicting ruptures.…”

Section: Discussionmentioning

confidence: 73%

“…[29] The supposed mechanisms involved their anti-inflammatory effects and their ability to stimulate the production of the extracellular matrix and the chemotactic migration of mesenchymal progenitor cells to stabilize the IA's parietal layers. [30] Interestingly, the largest case-control study to date, which involved 4701 patients with 6411 IAs, showed that use of a lipid-lowering agent was significantly inversely associated with RIA. [31] Subjects enrolled in the International Study of Unruptured Intracranial Aneurysms were compared regarding the frequency of aspirin use.…”

Section: Discussionmentioning

confidence: 99%

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Location of intracranial aneurysms is the main factor associated with rupture in the ICAN population

Rousseau

Karakachoff

Gaignard

et al. 2020

J Neurol Neurosurg Psychiatry

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Background and purposeThe ever-growing availability of imaging led to increasing incidentally discovered unruptured intracranial aneurysms (UIAs). We leveraged machine-learning techniques and advanced statistical methods to provide new insights into rupture intracranial aneurysm (RIA) risks.MethodsWe analysed the characteristics of 2505 patients with intracranial aneurysms (IA) discovered between 2016 and 2019. Baseline characteristics, familial history of IA, tobacco and alcohol consumption, pharmacological treatments before the IA diagnosis, cardiovascular risk factors and comorbidities, headaches, allergy and atopy, IA location, absolute IA size and adjusted size ratio (aSR) were analysed with a multivariable logistic regression (MLR) model. A random forest (RF) method globally assessed the risk factors and evaluated the predictive capacity of a multivariate model.ResultsAmong 994 patients with RIA (39.7%) and 1511 patients with UIA (60.3 %), the MLR showed that IA location appeared to be the most significant factor associated with RIA (OR, 95% CI: internal carotid artery, reference; middle cerebral artery, 2.72, 2.02–3.58; anterior cerebral artery, 4.99, 3.61–6.92; posterior circulation arteries, 6.05, 4.41–8.33). Size and aSR were not significant factors associated with RIA in the MLR model and antiplatelet-treatment intake patients were less likely to have RIA (OR: 0.74; 95% CI: 0.55–0.98). IA location, age, following by aSR were the best predictors of RIA using the RF model.ConclusionsThe location of IA is the most consistent parameter associated with RIA. The use of ‘artificial intelligence’ RF helps to re-evaluate the contribution and selection of each risk factor in the multivariate model.

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Section: Discussionmentioning

confidence: 73%

Section: Discussionmentioning

confidence: 99%

Location of intracranial aneurysms is the main factor associated with rupture in the ICAN population

Rousseau

Karakachoff

Gaignard

et al. 2020

J Neurol Neurosurg Psychiatry

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“…However, some studies have reported con icting results. For example, statin medication did not improve the healing rate of aneurysms in a rabbit model of unruptured aneurysms [21]. Additionally, a single-center case-control study including 1200 patients showed no signi cant bene cial effect of statin medication on IA inhibition [22].…”

Section: Discussionmentioning

confidence: 95%

The Association between Statin Medication Use and Intracranial Aneurysm Risk: A Two- Way Mendelian Randomization Study

Chen,

Huang,

Zhou

et al. 2024

Preprint

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Background Recent observational studies have identified a potential link between statin medication use and the risk of intracranial aneurysms (IAs). However, the causal relationship between these factors is not yet clear. Methods We used a two-way Mendelian randomization approach to examine the relationship between genetically predicted statin medication use and the risk of IAs, as well as the reverse association. We incorporated data from genome-wide association studies of statin medication and IAs in a European population. Our analysis relied on random-effects inverse variance weighted estimation as the primary statistical method. Results Neither statin medication use nor IA risk was significantly associated with the other, according to our findings. The odds ratio (OR) for statin medication was 1.551 (95% confidence interval [CI]: 0.895–2.685, P = 0.117), and the OR for IA risk was 1.020 (95% CI: 0.984–1.059, P = 0.281). Our results were consistent across different analytical methods, including MR-Egger regression and weighted median. Conclusions These findings suggest that there is no causal relationship between statin medication use and IA risk.

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“…[ 150 ] 2016 X Surgical Rabbits Saccular X Ding Y.H. [ 151 ] 2016 X Surgical Rabbits Saccular X Brinjikji W. [ 152 ] 2017 X Surgical Rabbits Saccular X Fahed R. [ 153 ] 2017 X Surgical Dogs Saccular X Miyamoto T. [ 154 ] 2017 X Endogenous Rats Saccular X …”

Section: Methodsmentioning

confidence: 99%

Imaging of intracranial aneurysms in animals: a systematic review of modalities

et al. 2023

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Intracranial aneurysm (IA) animal models are paramount to study IA pathophysiology and to test new endovascular treatments. A number of in vivo imaging modalities are available to characterize IAs at different stages of development in these animal models. This review describes existing in vivo imaging techniques used so far to visualize IAs in animal models. We systematically searched for studies containing in vivo imaging of induced IAs in animal models in PubMed and SPIE Digital library databases between 1 January 1945 and 13 July 2022. A total of 170 studies were retrieved and reviewed in detail, and information on the IA animal model, the objective of the study, and the imaging modality used was collected. A variety of methods to surgically construct or endogenously induce IAs in animals were identified, and 88% of the reviewed studies used surgical methods. The large majority of IA imaging in animals was performed for 4 reasons: basic research for IA models, testing of new IA treatment modalities, research on IA in vivo imaging of IAs, and research on IA pathophysiology. Six different imaging techniques were identified: conventional catheter angiography, computed tomography angiography, magnetic resonance angiography, hemodynamic imaging, optical coherence tomography, and fluorescence imaging. This review presents and discusses the advantages and disadvantages of all in vivo IA imaging techniques used in animal models to help future IA studies finding the most appropriate IA imaging modality and animal model to answer their research question.

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Statins are not associated with short-term improved aneurysm healing in a rabbit model of unruptured aneurysms

Abstract: Systemic statin administration after platinum coil embolization of unruptured aneurysms in a rabbit model does not improve aneurysm occlusion rates at 4 weeks.

Cited by 9 publications

References 23 publications

Location of intracranial aneurysms is the main factor associated with rupture in the ICAN population

Location of intracranial aneurysms is the main factor associated with rupture in the ICAN population

The Association between Statin Medication Use and Intracranial Aneurysm Risk: A Two- Way Mendelian Randomization Study

Imaging of intracranial aneurysms in animals: a systematic review of modalities

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