Statins—Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers

Granat, Marcin Mateusz; Eifler-Zydel, Joanna; Kolmas, Joanna

doi:10.3390/ijms25042378

Cited by 3 publications

(2 citation statements)

References 129 publications

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“…However, oral administration of statins, including simvastatin, presents some disadvantages. These include low solubility, limited bioavailability due to first-pass metabolism in the liver and impairment in the gastrointestinal tract (the oral bioavailability of simvastatin is less than 5%, w/w) [1,12,13], and side effects such as myopathy, kidney and liver damage, and rhabdomyolysis [14]. Therefore, there is a need to investigate alternative routes of statin administration for potential use in bone diseases, especially where prolonged action directly in bone tissue is required.…”

Section: Introductionmentioning

confidence: 99%

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Design of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications

Yaman,

Demir,

Bölgen

2024

Biomed. Mater.

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Tissue engineering aims to improve or restore damaged tissues by using scaffolds, cells and bioactive agents. In tissue engineering, one of the most important concepts is the scaffold because it has a key role in keeping up and promoting the growth of the cells. It is also desirable to be able to load these scaffolds with drugs that induce tissue regeneration/formation. Based on this, in our study, gelatin cryogel scaffolds were developed for potential bone tissue engineering applications and simvastatin loading and release studies were performed. Simvastatin is lipoliphic in nature and this form is called inactive simvastatin (SV). It is modified to be in hydrophilic form and converted to the active form (SVA). For our study's drug loading and release process, simvastatin was used in both inactive and active forms. The blank cryogels and drug-loaded cryogels were prepared at different glutaraldehyde concentrations (1, 2, and 3%). The effect of the crosslinking agent and the amount of drug loaded were discussed with morphological and physicochemical analysis. As the glutaraldehyde concentration increased gradually, the pores size of the cryogels decreased and the swelling ratio decreased. For the release profile of simvastatin in both forms, we can say that it depended on the form (lipophilic and hydrophilic) of the loaded simvastatin.

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Section: Introductionmentioning

confidence: 99%

“…In this context, with a topical application directly to the bone tissue by drug delivery systems (DDSs), hepatic metabolism can be bypassed, increasing bioavailability and allowing dose reduction. Thus, the risk of systemic side effects is reduced and the need for repeated administration of the drug can be eliminated [14].…”

Section: Introductionmentioning

confidence: 99%

Design of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications

Yaman,

Demir,

Bölgen

2024

Biomed. Mater.

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Systemic Statin Use and Pulp Chamber Calcification: A Pilot Retrospective Case-Control Study Using Cone-Beam Computed Tomography

Sisli,

Ozasir,

Ozasir

et al. 2024

Med Princ Pract

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Objectives: This pilot retrospective case-control study questioned whether systemic statin use causes pulp calcification using cone-beam computed tomography images from the patients prescribed oral statins and comparing those of healthy individuals. Subjects and Methods: CBCT scans of 54 patients, including 27 age- and sex-matched patients for the study and control groups, were analysed using Mimics Innovation Suite software. The study included patients using statins regularly for at least 1 year. Only intact teeth with opposing teeth were selected for the study group and matched with the control group. Dental crown and pulp chamber volumes were calculated and proportioned. The data were analysed with chi-square and Shapiro-Wilk tests to assess normal distribution, followed by Mann-Whitney U test if necessary. Results: Statistical analysis showed no difference between the study and control groups (p = 0.505). Statin use duration did not cause statistically significant difference in terms of the reduction of pulp chamber volume (p = 0.141). Conclusion: Within the limitations of the study, systemic statin use did not cause dental pulp calcification. The results suggest, oral administration of the statin drugs is not an unfavourable condition for dental practice. Further studies with larger numbers of patients are needed to support this conclusion.

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Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity

Wang,

Bei,

Zhang

et al. 2025

Crit Rev Immunol

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The objective of this study was to provide guidelines to clinicians for the evaluation, treatment, and prevention of vitamin D deficiency with an emphasis on the care of patients who are at risk for obesity and diabetes. Our aim was to determine the relationship between vitamin D3 and metabolic syndrome, and investigate the effect of vitamin D3 supplementation on hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity. We conducted a study between January 2018 and January 2020, with a total of 723 children invited to participate. Of these, 283 were in the vitamin D supplement group (SG) and 440 were in the placebo group (PG). We evaluated blood pressure, fasting glucose, high-density lipoprotein, total cholesterol, low-density lipoprotein, and bone mineral density (BMD) in all subjects. We observed that cholesterol, triglyceride, and glucose levels were strongly associated with 25(OH)D3 levels at baseline. After vitamin D3 supplementation, we observed a significant increase in body mass index (BMI) (P = 0.02) and serum 25(OH)D3 (P < 0.01) levels in the vitamin D3 group compared to the placebo group. Additionally, serum lipids such as total cholesterol (P <0.01), HDL-c (P < 0.01), total cholesterol/HDL-c (P < 0.01), LDL-c/HDL-c (P < 0.01), and triglycerides/HDL-c (P < 0.01) were significantly decreased in the vitamin D group compared to the placebo group. Serum vitamin D3 was inversely associated with cholesterol, triglycerides, and fasting glucose. Our results suggest that vitamin D3 supplementation enhances the beneficial effect of hyperlipidemia, glucose metabolism, and bone mass in pediatric patients with obesity.

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Statins—Their Role in Bone Tissue Metabolism and Local Applications with Different Carriers

Cited by 3 publications

References 129 publications

Design of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications

Design of gelatin cryogel scaffolds with the ability to release simvastatin for potential bone tissue engineering applications

Systemic Statin Use and Pulp Chamber Calcification: A Pilot Retrospective Case-Control Study Using Cone-Beam Computed Tomography

Vitamin D Supplementation Reduces Hyperlipidemia and Improves Bone Mass in Pediatric Obesity

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