Stationary micro-CT scanner using a distributed multi-beam field emission x-ray source: a feasibility study

Peng, Rui; Zhang, J.; Calderón‐Colón, Xiomara; Wang, S.; Sultana, Shabana; Chang, S; Lü, Jianping; Zhou, Otto

doi:10.1117/12.811467

Cited by 10 publications

(12 citation statements)

References 13 publications

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“…With a higher emission current from the CNT cathode, the system temporal resolution can be increased to be better than 10 ms while maintaining the CNR used in the present study. The development of the spatially distributed CNT x-ray source array technology can potentially lead to a stationary micro-CT scanner with a much faster scanning speed 12 and with multiple energy capability.…”

Section: Discussionmentioning

confidence: 99%

“…8 The technology further enables the fabrication of spatially distributed source arrays that can produce a scanning x-ray beam without mechanical motion, which is now being actively investigated for a variety of medical imaging devices [9][10][11] including stationary micro-CT scanners with ultrahigh scanning speed. 12 We have previously reported the development of a micro-CT scanner using a single-beam CNT microfocus x-ray source housed in a large and stationary vacuum chamber. 13,14 Using this scanner with the stationary source and detector geometry, we demonstrated the feasibility of high-resolution respiratory-gated micro-CT imaging of freebreathing mice.…”

Section: Introductionmentioning

confidence: 99%

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Prospective‐gated cardiac micro‐CT imaging of free‐breathing mice using carbon nanotube field emission x‐ray

et al. 2010

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Purpose: Carbon nanotube ͑CNT͒ based field emission x-ray source technology has recently been investigated for diagnostic imaging applications because of its attractive characteristics including electronic programmability, fast switching, distributed source, and multiplexing. The purpose of this article is to demonstrate the potential of this technology for high-resolution prospective-gated cardiac micro-CT imaging. Methods: A dynamic cone-beam micro-CT scanner was constructed using a rotating gantry, a stationary mouse bed, a flat-panel detector, and a sealed CNT based microfocus x-ray source. The compact single-beam CNT x-ray source was operated at 50 KVp and 2 mA anode current with 100 m ϫ 100 m effective focal spot size. Using an intravenously administered iodinated bloodpool contrast agent, prospective cardiac and respiratory-gated micro-CT images of beating mouse hearts were obtained from ten anesthetized free-breathing mice in their natural position. Fourdimensional cardiac images were also obtained by gating the image acquisition to different phases in the cardiac cycle. Results: High-resolution CT images of beating mouse hearts were obtained at 15 ms temporal resolution and 6.2 lp/mm spatial resolution at 10% of system MTF. The images were reconstructed at 76 m isotropic voxel size. The data acquisition time for two cardiac phases was 44Ϯ 9 min. The CT values observed within the ventricles and the ventricle wall were 455Ϯ 49 and 120Ϯ 48 HU, respectively. The entrance dose for the acquisition of a single phase of the cardiac cycle was 0.10 Gy. Conclusions: A high-resolution dynamic micro-CT scanner was developed from a compact CNT microfocus x-ray source and its feasibility for prospective-gated cardiac micro-CT imaging of free-breathing mice under their natural position was demonstrated.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prospective‐gated cardiac micro‐CT imaging of free‐breathing mice using carbon nanotube field emission x‐ray

et al. 2010

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“…The project images will be collected by selectively activating the X-ray beams from different projection angles without mechanical motion of the object or the source. The feasibility of such a system was recently demonstrated in our lab using a prototype 20-beam microfocus MBFEX source [63]. There is also an ongoing development effort in the reconstruction algorithm [62].…”

Section: Conclusion and Future Directionmentioning

confidence: 99%

Carbon Nanotube X‐Ray for Dynamic Micro‐CT Imaging of Small Animal Models

Zhou

Cao

Lee

et al. 2011

Nanoplatform‐Based Molecular Imaging

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“…The electrostatic lenses are especially important in so called stationary computed tomography (CT) scans with distributed X-ray tubes [12,14] where hundreds of X-ray sources surround the patient [14]. Depending on applications, electron optics systems can have different combination of electrostatic lenses [15][16][17][18]. Of particular interest are single lens electron optics systems, in which only one lens is located between gating grid and anode.…”

Section: Introductionmentioning

confidence: 99%

Design of TiO_{2} nanotube based X-ray tube with single focusing electrode

Alivov

Feng

Molloi

2013

Journal of X-Ray Science and Technology

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We studied in details the effect of various X-ray tube parameters (cathode size, anode size, anode -lens distance, etc.) on TiO2 nanotube field emission electron-beam focal spot size (FSS) and lens voltages for a single electrode lens system. The simulations were performed using commercially available SIMION 8.1 software. A wide range of parameters was simulated to determine conditions when FSS and lens focusing voltage had minimum values. In particular, the dependence of FSS and lens voltages on cathode size (dS) was studied for different size lens apertures (dL) and different anode voltages. The cathode size dS was varied in the range from 0.1 mm to dL; the dL was changed from 4 to 24 mm in 4 mm increments. The simulations were performed for two different VA values 60 kV and 120 kV. It was found that for 20 mm and 24 mm diameter lens apertures the maximum cathode size when the resulting FSS was not greater than 1600 µm (the focal spot size in clinical X-ray CT) were 17.5 mm and 16.2 mm, respectively. The lens voltages V f corresponding to 17.5 mm and 16.2 mm cathode size in 20 mm and 24 mm aperture diameter x-ray tubes are 1850 V and −1550 V, respectively.

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Stationary micro-CT scanner using a distributed multi-beam field emission x-ray source: a feasibility study

Cited by 10 publications

References 13 publications

Prospective‐gated cardiac micro‐CT imaging of free‐breathing mice using carbon nanotube field emission x‐ray

Prospective‐gated cardiac micro‐CT imaging of free‐breathing mice using carbon nanotube field emission x‐ray

Carbon Nanotube X‐Ray for Dynamic Micro‐CT Imaging of Small Animal Models

Design of TiO_{2} nanotube based X-ray tube with single focusing electrode

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