Recycled crumb rubber can be sustainable used in mortar both to mitigate nature aggregate consumption, reducing environmental pollution, as well, to improve the acoustic and thermal performance of buildings, without damaging its mechanical properties. This paper explores workability, microstructure, mechanical, thermal and acoustic properties considering increasing contents of crumb rubber (0%, 5%, 10%, 15% and 20% replacement, by volume, of fine aggregate). Mortar characterization tests were carried out in the fresh and hardened state. It has been found that replacing the aggregate with scrap tyre rubber reduced the compressive strength on average 12% and 67% and for tensile strength 35% and 53%, for the contents of 10% and 20% respectively, compared to the reference. Furthermore, it was found that the reductions in thermal conductivity reached 16% and 29% and an increase in acoustic attenuation on average 12% and 13%. Moreover, scanning electron microscopy images were analyzed, justifying the mechanical results obtained. Although the experimental results indicated that the workability and mechanical strengths decreased with the increase of rubber replacement rate, the studied mixtures met the standard specifications, and thus suitable for walls and ceilings coating applications, improve the acoustic and thermal performance of buildings and as a sustainable material.