Statistical analysis of multi-subject fMRI data: Assessment of focal activations

Bosch, Volker

doi:10.1002/(sici)1522-2586(200001)11:1<61::aid-jmri9>3.0.co;2-c

Cited by 113 publications

(82 citation statements)

References 3 publications

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“…The statistical analysis was based on a least squares estimation using the general linear model (GLM) for serially autocorrelated observations Bosch, 2000;Friston, 1994;Zarahn et al, 1997]. For each individual subject, statistical parametric maps (SPM) were generated with the standard hemodynamic response function and a response delay of 6 sec.…”

Section: Discussionmentioning

confidence: 99%

“…As the individual functional datasets were all aligned to the same stereotactic reference space a group analysis of fMRI-data was performed by averaging individual Z-maps. The average SPM was multiplied by a SPM correction factor of the square root of the current number of subjects (n ϭ 14) [Bosch, 2000]. For the purpose of illustration, averaged data were superimposed onto one normalized 3D MDEFT standard volume.…”

Section: Discussionmentioning

confidence: 99%

“…To test whether brain responses to prosodic speech are more strongly lateralized to right peri-sylvian areas as compared to the remaining sentence conditions statistical testing by means of spherical regions of ᭜ Neurocognition of Prosodic Processing in Sentence Level Speech Comprehension ᭜ ᭜ 77 ᭜ interest (ROIs) was performed [Bosch, 2000]. Functional activation of each condition was calculated separately.…”

Section: Region Of Interest Analysesmentioning

confidence: 99%

“…In a second step normalized Z-scores were averaged within 3 bilateral spherical ROIs of each participant yielding mean Z-scores for each condition [Bosch, 2000]. The mean Z-scores were subjected to repeatedmeasures ANOVA to analyze differences in local brain activation across subjects and between conditions.…”

Section: Region Of Interest Analysesmentioning

confidence: 99%

“…The results of a further statistical analysis using spherical regions of interest (ROIs) addresses this issue exclusively. Figure 3 indicates mean Z-scores for experimental conditions obtained from six bilateral spherical ROIs [Bosch, 2000] whose positions are shown in Figure 2.…”

Section: Syntactic Vs Prosodic Speechmentioning

confidence: 99%

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FMRI reveals brain regions mediating slow prosodic modulations in spoken sentences

Meyer

Alter

Friederici

et al. 2002

Human Brain Mapping

291

176

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By means of fMRI measurements, the present study identifies brain regions in left and right peri-sylvian areas that subserve grammatical or prosodic processing. Normal volunteers heard 1) normal sentences; 2) so-called syntactic sentences comprising syntactic, but no lexical-semantic information; and 3) manipulated speech signals comprising only prosodic information, i.e., speech melody. For all conditions, significant blood oxygenation signals were recorded from the supratemporal plane bilaterally. Left hemisphere areas that surround Heschl gyrus responded more strongly during the two sentence conditions than to speech melody. This finding suggests that the anterior and posterior portions of the superior temporal region (STR) support lexical-semantic and syntactic aspects of sentence processing. In contrast, the right superior temporal region, in especially the planum temporale, responded more strongly to speech melody. Significant brain activation in the fronto-opercular cortices was observed when participants heard pseudo sentences and was strongest during the speech melody condition. In contrast, the fronto-opercular area is not prominently involved in listening to normal sentences. Thus, the functional activation in fronto-opercular regions increases as the grammatical information available in the sentence decreases. Generally, brain responses to speech melody were stronger in right than left hemisphere sites, suggesting a particular role of right cortical areas in the processing of slow prosodic modulations. Hum. Brain Mapping 17:73-88, 2002.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Region Of Interest Analysesmentioning

confidence: 99%

Section: Region Of Interest Analysesmentioning

confidence: 99%

Section: Syntactic Vs Prosodic Speechmentioning

confidence: 99%

See 3 more Smart Citations

FMRI reveals brain regions mediating slow prosodic modulations in spoken sentences

Meyer

Alter

Friederici

et al. 2002

Human Brain Mapping

291

176

View full text Add to dashboard Cite

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Dissociation of memory retrieval and search processes: An event-related fMRI study

Pollmann

Zysset

Wiggins

et al. 2000

Microsc. Res. Tech.

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What have Klingon letters and faces in common? An fMRI study on content-specific working memory systems

Mecklinger¹,

Bosch²,

Gruenewald³

et al. 2000

Hum. Brain Mapp.

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Neuroimaging studies show that prefrontal, premotor, and parietal cortical regions are part of a working memory network that supports the active retention of information. In two experiments we used fMRI to examine whether prefrontal and posterior cortical areas are organized in a content‐specific way for object and spatial working memory. Subjects performed a delayed matching‐to‐sample task modified to allow the examination of content‐specific retention processes, independent of perceptual and decision‐related processes. In Experiment 1, either unfamiliar geometrical objects (Klingon letters from an artificial alphabet unknown to the participants) or their spatial locations had to be memorized, whereas in Experiment 2, either unfamiliar faces or biological objects (butterflies) were actively memorized. All tasks activated a similar cortical network including posterior parietal (banks of the intraparietal sulcus), premotor (banks of the inferior precentral sulcus) and prefrontal regions (banks of the inferior frontal sulcus), and the presupplementary motor area (pre‐SMA). For geometrical objects and faces for which strategic semantic processing can be assumed, this activation was larger in the left than in the right hemisphere, whereas a bilateral or right dominant distribution was obtained for butterflies and spatial locations. The present results do not support the process‐specific or content‐specific view of the role of the prefrontal cortex in working memory task. Rather, they suggest that the inferior prefrontal cortex houses nonmemonic strategic processing systems required for response selection and task management that can flexibly be used across a variety of tasks and informational domains. Hum. Brain Mapping 11:146–161, 2000. © 2000 Wiley‐Liss, Inc.

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Statistical analysis of multi-subject fMRI data: Assessment of focal activations

Cited by 113 publications

References 3 publications

FMRI reveals brain regions mediating slow prosodic modulations in spoken sentences

FMRI reveals brain regions mediating slow prosodic modulations in spoken sentences

Dissociation of memory retrieval and search processes: An event-related fMRI study

What have Klingon letters and faces in common? An fMRI study on content-specific working memory systems

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