Statistical analysis on the variables affecting itaconic acid separation by bipolar membrane electrodialysis

Komáromy, Péter; Rózsenberszki, Tamás; Bakonyi, Péter; Nemestóthy, Nándor; Bélafi–Bakó, Katalin

doi:10.5004/dwt.2020.25899

Cited by 8 publications

(5 citation statements)

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“…Thus, the test solutions contained Processes 2020, 8, 1031 5 of 13 glucose to simulate the residual substrate. Previous experiments showed that IA separation from simple model solutions could be managed and reached a CE of over 91% with a similar system configuration and parameter settings (pH = 5, 20 V applied potential and 33 g/L IA model solutions) [21]. During a continuous operation, the presence of the substrate and, furthermore, the production of by-products such as succinic, malic acid, alpha-ketoglutaric acid, fumaric acid etc.…”

Section: Resultsmentioning

confidence: 98%

“…It is also supported by our previous work, where a similar system was investigated using model solutions with initial IA concentrations, initial pHs and applied potentials of 5-60 g/L, 2-8, 10-30 V, respectively. The peak CE value (up to 97 %) was achieved under the following conditions: 33 g IA/L, pH = 5 and 20 V as applied potential [21]. This means that more undesired mobile ions such as other organic ions (not only MA) in the bulk phase could decrease permselectivity.…”

Section: Effects Of Ia Fermentation Substrate and By-productmentioning

confidence: 95%

“…The following flow (recirculation) rates were maintained during operation: C base : 50 L/h; D: 50 L/h; C acid : 50 L/h; E: 60 L/h. The feed solutions were formulated as stated in Table 3, based on our previous experiences with IA production and separation [21,22]. The conductance of the solutions (in tanks D, C base , C acid ) over time was measured by a Radelkis OK-102/1 conductivity meter connected to a Radelkis OK-9023 bell electrode using a cell constant of 0.7 cm −1 .…”

Section: Methodsmentioning

confidence: 99%

“…Apart from the effect of EDBM inlet composition and its pH, the impact of applied potential on the IA recovery ratio and current efficiency (CE) was tested experimentally using a commercialized electrodialysis apparatus. The experimental conditions were considered based on our previous, relevant work [21]. To our knowledge, this subject has not yet been specifically investigated, and the data generated and assessed in this paper show an added value that may enrich the literature.…”

Section: Introductionmentioning

confidence: 99%

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Investigation of Itaconic Acid Separation by Operating a Commercialized Electrodialysis Unit with Bipolar Membranes

et al. 2020

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Nowadays, the merging of membrane and fermentation technologies is receiving significant attention such as in the case of itaconic acid (IA) production, which is considered as a value-added chemical. Its biotechnological production is already industrially established; however, the improvements of its fermentative and recovery steps remain topics of significant interest due to sustainable development trends. With an adequate downstream process, the total price of IA production can be reduced. For the task of IA recovery, a contemporary electro-membrane separation processes, electrodialysis with bipolar membranes (EDBM), was proposed and employed in this work. In the experiments, the laboratory-scale, commercialized EDBM unit (P EDR-Z/4x) was operated to separate IA from various model solutions compromised of IA (5–33 g/L), glucose (varied in 15–33 g/L as a residual substrate during IA fermentation) and malic acid (varied in 0–1 g/L as a realistic by-product of IA fermentation) under different initial pH (2–5) and applied potential conditions (10–30 V). Unambiguously negative effects related to the glucose and malic acid as impurities were found neither on the IA recovery ratio nor on the current efficiency, falling into the ranges of 90–97% and 74.3–98.5%, respectively. The highest IA recovery ratios of 97% and 98.5% of current efficiency were obtained with the model fermentation solution containing 33 g/L IA, 33 g/L glucose at 20 V and an initial pH of 5. However, the selective separation of IA needs further investigations with a real fermentation broth, and the findings of this research may contribute to further studies in this field.

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Section: Resultsmentioning

confidence: 98%

Section: Effects Of Ia Fermentation Substrate and By-productmentioning

confidence: 95%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Investigation of Itaconic Acid Separation by Operating a Commercialized Electrodialysis Unit with Bipolar Membranes

et al. 2020

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“…In the case of IA, the applicability of EDBM was proven in our laboratory not only from model solutions [6]- [7] but also on a real, clarified fermentation broth [8]. In the following step, our goal was to implement a continuous fermentation with a relevant titer of IA in the effluent.…”

Section: Introductionmentioning

confidence: 99%

Case Study of Continuous Itaconic Acid Fermentation by Aspergillus Terreus in a Bench-Scale Bioreactor

Hülber-Beyer,

Nemestóthy,

Bélafi-Bakó

2023

Hung. J. Ind. Chem.

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Itaconic acid (IA) is a highly important bioproduct. The traditional biotechnological production of organic acids generates large quantities of biomass and water streams as waste. Bipolar membrane electrodialysis is a suitable technique for directly recovering IA from clarified fermentation broth whereby itaconic acid is separated without chemical loading. As a result, the remaining diluate stream can be reintroduced into the fermentation process. This membrane operation can be integrated into a continuous fermentation process in order to carry out the process using a high glucose concentration in the effluent, opening up new possibilities for the implementation of continuous itaconic acid fermentation. In this study, a possible highly successful implementation of this technique is presented. The applied gentle stirring technique as well as the low dilution rate of 0.007 s-1 is necessary to be complemented by highly efficient oxygenation, thereby promoting itaconic acid generation. With an inlet supplying pure oxygen gas, the acid accumulated and an average of 30.1 g·L-1 titer of IA was achieved in the effluent. The volumetric oxygen uptake rate was monitored during the fermentation which fluctuated from 40-88% so further investigation of this may be worthwhile in the future.

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Bio‐CarboxylicAcid Separation by Ionic Liquids

Kumar,

Antony,

Shende

et al. 2023

Handbook of Ionic Liquids

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Statistical analysis on the variables affecting itaconic acid separation by bipolar membrane electrodialysis

Cited by 8 publications

References 0 publications

Investigation of Itaconic Acid Separation by Operating a Commercialized Electrodialysis Unit with Bipolar Membranes

Investigation of Itaconic Acid Separation by Operating a Commercialized Electrodialysis Unit with Bipolar Membranes

Case Study of Continuous Itaconic Acid Fermentation by Aspergillus Terreus in a Bench-Scale Bioreactor

Bio‐CarboxylicAcid Separation by Ionic Liquids

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