Statistical and practical issues in the design of a national probability sample of births for the Vanguard Study of the National Children's Study

Montaquila, Jill M.; Brick, J. Michael; Curtin, Lester R.

doi:10.1002/sim.3891

Cited by 32 publications

(28 citation statements)

References 5 publications

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“…Initially, women were recruited based on NCS Vanguard Study protocols (Baker et al 2014; Montaquila et al 2010). For the Vanguard Study, Orange County, California was divided into 15 geographical strata, which were each then further divided into 11 geographical units (GUs).…”

Section: Methodsmentioning

confidence: 99%

Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women

Luderer

Christensen

Johnson

et al. 2017

Environment International

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Essentially all women are exposed to polycyclic aromatic hydrocarbons (PAHs), formed during incomplete combustion of organic materials, including fossil fuels, wood, foods, and tobacco. PAHs are ovarian toxicants in rodents, and cigarette smoking is associated with reproductive abnormalities in women. Biomonitoring of hydroxylated PAH (OH-PAH) metabolites in urine provides an integrated measure of exposure to PAHs via multiple routes and has been used to characterize exposure to PAHs in humans. We hypothesized that concentrations of OH-PAHs in urine are associated with reproductive function in women. We recruited women 18–44 years old, living in Orange County, California to conduct daily measurement of urinary luteinizing hormone (LH) and estrone 3-glucuronide (E13G) using a microelectronic fertility monitor for multiple menstrual cycles; these data were used to calculate endocrine endpoints. Participants also collected urine samples on cycle day 10 for measurement of nine OH-PAHs. Models were constructed for eight endpoints using a Bayesian mixed modeling approach with subject-specific random effects allowing each participant to act as a baseline for her set of measurements. We observed associations between individual OH-PAH concentrations and follicular phase length, follicular phase LH and E13G concentrations, preovulatory LH surge concentrations, and periovulatory E13G slope and concentration. We have demonstrated the feasibility of using urinary reproductive hormone data obtained via fertility monitors to calculate endocrine endpoints for epidemiological studies of ovarian function during multiple menstrual cycles. The results show that environmental exposure to PAHs is associated with changes in endocrine markers of ovarian function in women in a PAH-specific manner.

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Section: Methodsmentioning

confidence: 99%

Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women

Luderer

Christensen

Johnson

et al. 2017

Environment International

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“…Women (ages 18–49 years) were invited to participate in focus groups conducted in seven socioeconomically diverse cities in Orange County, California. We intentionally recruited women who were not eligible for the National Children’s Study due to their geographic location (to avoid placing an additional burden on communities that would be approached and asked to participate in the NCS), but who would be representative of the communities selected for participation in the NCS in Orange County [for a description of the household probability sampling methods used to identify NCS segments, see Montaquila et al, 2010 and Baker et al, 2011]. The Orange County Vanguard Center community outreach team worked with community partners to distribute study flyers targeting mothers or expectant mothers in the selected communities.…”

Section: Methodsmentioning

confidence: 99%

Maternal perspectives on the return of genetic results: Context matters

Lakes

Vaughan

Lemke

et al. 2012

American J of Med Genetics Pt A

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The objectives of this study were to study maternal preferences for the return of their child’s genetic results and to describe the experiences, perceptions, attitudes and values that are brought to bear when individuals from different racial and cultural backgrounds consider participating in genetic research. We recruited women with diverse sociodemographic profiles to participate in seven focus groups. Twenty-eight percent of participants self-identified as Hispanic; 49% as White, Non-Hispanic; and 21% as Asian or Asian American. Focus groups were conducted in English or Spanish and were audio-recorded and transcribed verbatim. Transcripts were analyzed using qualitative thematic methods. Results indicated that preferences and decisions regarding the return of results may depend on both research and individual contextual factors. Participants understood the return of results as a complex issue, where individual and cultural differences in preferences are certain to arise. Another key finding was that participants desired an interpersonal, dynamic, flexible process that accommodated individual preferences and contextual differences for returning results. Our findings indicate a need to have well-developed systems for allowing participants to make and change over time their choices regarding the return of their child’s genetic results.

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“…The multistage sampling scheme involved selection of geographic areas, with a goal of enrolling all births to women in the sample area during the enrollment period. The considerations and challenges of this sampling design are described by Montaquila et al [10], and the importance of a national probability sample and participant retention for the NCS to meet its intended goals is described by Ellenberg [11]. At present, alternative recruitment strategies are being considered, and the goal has been retained for the NCS to enroll a sample that will provide results that can be generalized to the US population.…”

Section: National Children's Study Samplementioning

confidence: 99%

The National Children’s Study: An Opportunity for Medical Toxicology

Mortensen¹,

Hirschfeld²

2011

J. Med. Toxicol.

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The National Children's Study (NCS) is a national longitudinal study that will prospectively investigate the influence of biological, environmental, genetic, and social factors on the health and development of US children. The NCS was mandated by the Children's Health Act of 2000 (Public Law 106-310) and is being implemented by the National Institutes of Health with input from the Centers for Disease Control and Prevention (CDC), the Environmental Protection Agency, and other federal departments and agencies. The NCS is a data-driven, evidencebased, community-and participant-informed study. Given its scale and scope, the NCS is an integrated system using several data acquisition strategies intended to provide evidenced-based design of methodologies and protocols. These strategies include the Vanguard Study, the Main Study, and formative research and sub-studies. The Vanguard Study, a pilot study, is currently underway and has been expanded from 7 to 37 study locations. The original study protocols and recruitment strategy have been field tested and revisions are under consideration. The CDC is collaborating with NCS in a pilot study that evaluates biological specimen protocols and will provide results on a broad array of environmental chemical exposures and nutritional indicators for a sample of Vanguard Study participants. This study is an example of the kind of collaborative opportunity that would benefit the NCS. Medical toxicologists have unique training in basic and clinical toxicology and laboratory assessments, and by partnering with study centers, both the NCS design and future NCS research projects could be enhanced.

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Statistical and practical issues in the design of a national probability sample of births for the Vanguard Study of the National Children's Study

Cited by 32 publications

References 5 publications

Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women

Associations between urinary biomarkers of polycyclic aromatic hydrocarbon exposure and reproductive function during menstrual cycles in women

Maternal perspectives on the return of genetic results: Context matters

The National Children’s Study: An Opportunity for Medical Toxicology

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