2014
DOI: 10.33320/maced.pharm.bull.2014.60.01.003
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Statistical approach for selection of regression model during validation of bioanalytical method

Abstract: The selection of an adequate regression model is the basis for obtaining accurate and reproducible results during the bionalytical method validation. Given the wide concentration range, frequently present in bioanalytical assays, heteroscedasticity of the data may be expected. Several weighted linear and quadratic regression models were evaluated during the selection of the adequate curve fit using nonparametric statistical tests: One sample rank test and Wilcoxon signed rank test for two independent groups of… Show more

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