Statistical Assessment of Perceptual CT Scan Ratings in Patients with Alzheimer Type Dementia

LeMay, Marjorie; Stafford, Juliene L.; Sándor, Tamás; Albert, Marilyn; Haykal, Hani A.; Zamani, Amir A.

doi:10.1097/00004728-198609000-00018

Cited by 61 publications

(18 citation statements)

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“…The regions that showed the greatest difference were the lateral and third ventricles (40,41) and parts of the temporal lobe, such as the CSF areas around the Sylvian fissures and the tips of the temporal horns (42,43). Alzheimers, but not Huntingtons, disease affects the suprasellar cistern (12), suggesting that atrophy of the frontal-temporal basal forebrain areas could be associated with cognitive decline in Alzheimers disease (12).…”

Section: Discussionmentioning

confidence: 99%

Diagnosing dementia and normal aging: clinical relevance of brain ratios and cognitive performance in a Brazilian sample

Chaves

Ilha

Maia

et al. 1999

Braz J Med Biol Res

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The main objective of the present study was to evaluate the diagnostic value (clinical application) of brain measures and cognitive function. Alzheimer and multiinfarct patients (N = 30) and normal subjects over the age of 50 (N = 40) were submitted to a medical, neurological and cognitive investigation. The cognitive tests applied were Mini-Mental, word span, digit span, logical memory, spatial recognition span, Boston naming test, praxis, and calculation tests. The brain ratios calculated were the ventricle-brain, bifrontal, bicaudate, third ventricle, and suprasellar cistern measures. These data were obtained from a brain computer tomography scan, and the cutoff values from receiver operating characteristic curves. We analyzed the diagnostic parameters provided by these ratios and compared them to those obtained by cognitive evaluation. The sensitivity and specificity of cognitive tests were higher than brain measures, although dementia patients presented higher ratios, showing poorer cognitive performances than normal individuals. Normal controls over the age of 70 presented higher measures than younger groups, but similar cognitive performance. We found diffuse losses of tissue from the central nervous system related to distribution of cerebrospinal fluid in dementia patients. The likelihood of case identification by functional impairment was higher than when changes of the structure of the central nervous system were used. Cognitive evaluation still seems to be the best method to screen individuals from the community, especially for developing countries, where the cost of brain imaging precludes its use for screening and initial assessment of dementia.

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Section: Discussionmentioning

confidence: 99%

Diagnosing dementia and normal aging: clinical relevance of brain ratios and cognitive performance in a Brazilian sample

Chaves

Ilha

Maia

et al. 1999

Braz J Med Biol Res

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“…A similar approach to assessing regional brain anatomy on CT in neurological and psychiatric patients was described elsewhere (Benes et al 1983;LeMay et al 1986;McCarley et al 1989). Briefly, a 7-point scale was constructed for rating the frontal, temporal, and parietal lobes, as well as the ventricular system.…”

Section: Ct Scans and Scoringmentioning

confidence: 99%

Temporal lobe abnormalities in multigenerational families with schizophrenia

Honer

Bassett

Smith

et al. 1994

Biological Psychiatry

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Brain structure in familial schizophrenia was studied with computerized tomography in 42 individuals from six multigenerational families. Sulcal enlargement in the lateral temporal cortex, and ventricular and cisternal enlargement in the medial temporal region were observed in psychotic individuals compared to unaffected family members. Genetic factors in familial schizophrenia may exert part of their effect through determining or altering temporal lobe structure.

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“…Both CT (LeMay et al, 1986;Kido et al, 1989;George et al, 1990;Jobst et al, 1992;de Leon et al, 1993;Pasquier et al, 1997) and MRI (Seab et al, 1988;Jack et al, 1992;Scheltens et al, 1992;Erkinjuntti et al, 1993;O'Brien et al, 1994) studies conducted on atrophy of the medial temporal lobes have suggested the usefulness of this test in supporting the diagnosis of AD. Studies have established the primary role of the hippocampus and related MTL structures in memory formation (Squire, 1992).…”

Section: Introductionmentioning

confidence: 99%

CT measurement of medial temporal lobe atrophy in Alzheimer's disease, vascular dementia, depression and paraphrenia

Denihan

Wilson

Cunningham

et al. 2000

Int. J. Geriat. Psychiatry

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Statistical Assessment of Perceptual CT Scan Ratings in Patients with Alzheimer Type Dementia

Cited by 61 publications

References 0 publications

Diagnosing dementia and normal aging: clinical relevance of brain ratios and cognitive performance in a Brazilian sample

Diagnosing dementia and normal aging: clinical relevance of brain ratios and cognitive performance in a Brazilian sample

Temporal lobe abnormalities in multigenerational families with schizophrenia

CT measurement of medial temporal lobe atrophy in Alzheimer's disease, vascular dementia, depression and paraphrenia

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