Statistical assessment of the synergistic effect between a vaccine and a drug

Ζιντζαράς, Ηλίας

doi:10.1111/j.2042-7158.1992.tb03225.x

Cited by 2 publications

(1 citation statement)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The data were analysed raw since such results can be interpreted to clinicians more easily and the logit model for discriminant analysis may hold in the absence of normality [4], although any conclusions must be drawn cautiously. In addition, data transformation may mask the real effects of the parameters and their interactions [7]. Figure 1 shows typical distributions of ADA and CRP after logarithmic transformation.…”

Section: Resultsmentioning

confidence: 99%

Discrimination of exudative pleural effusions based on multiple biological parameters

Daniil

Ζιντζαράς²,

Kiropoulos³

et al. 2007

Eur Respir J

View full text Add to dashboard Cite

Pleural effusion is a common complication of various diseases. Conventional methods are not always capable of establishing the cause of pleural effusion, so alternative tests are needed. The aim of this study was to explore means of discriminating between different pleural effusion groups, malignant, parapneumonic and tuberculous, based on the combined function of seven biological markers.Adenosine deaminase (ADA), interferon-c, C-reactive protein (CRP), carcinoembryonic antigen, interleukin-6, tumour necrosis factor-a and vascular endothelial growth factor concentration levels were measured in pleural fluid from 45 patients with malignant, 15 with parapneumonic and 12 with tuberculous pleural effusion. Receiver operating characteristic curve analysis, multinomial logit modelling and canonical variate analysis were applied to discriminate the pleural effusion groups.The three groups could be discriminated successfully using the measured markers. The most important parameters for discrimination were ADA and CRP concentration levels. An individual with an ADA concentration level of .45 U?L -1 and a CRP concentration of ,4 mg?dL -1 was more likely to belong to the tuberculous pleural effusion group, whereas one with an ADA concentration level of ,40 U?L -1 and a CRP concentration of .6 mg?dL -1 was more likely to belong to the parapneumonic pleural effusion group, and one with a CRP concentration of ,4 mg?dL -1 to the malignant pleural effusion group. The combination of adenosine deaminase and C-reactive protein levels might be sufficient for discriminating between the three different groups of exudative pleural effusion: malignant, tuberculous and parapneumonic.

show abstract

Section: Resultsmentioning

confidence: 99%

Discrimination of exudative pleural effusions based on multiple biological parameters

Daniil

Ζιντζαράς²,

Kiropoulos³

et al. 2007

Eur Respir J

View full text Add to dashboard Cite

show abstract

A bioequivalence study of Levothyroxine tablets versus an oral Levothyroxine solution in healthy volunteers

Yannovits¹,

Ζιντζαράς

Pouli³

et al. 2006

European Journal of Drug Metabolism and Pharmacokinetics

View full text Add to dashboard Cite

Probably for genetic reasons a substantial part of the Greek population requires Levothyroxine treatment. Since commercially available Levothyroxine was first marketed, the manufacture and storage of the drug in tablet form has been complicated and difficult; and as cases of therapeutic failure have frequently been reported following treatment with this medicinal agent, quality control is an essential factor. Due to the unreliability of Levothyroxine-based commercial products, in the present study we decided to follow the Food and Drug Administration (FDA) guidelines*, and use a Levothyroxine solution as reference product. The bioavailability of the Levothyroxine sodium tablet formulation THYROHORMONE/Ni-The Ltd (0.2 mg/tab) and that of a reference oral solution (0.3 mg/100 ml) under fasting conditions were compared in an open, randomized, single-dose two-way crossover study. Twenty four healthy Caucasian volunteers (M/F=15/9, mean age=32.9+/-7.4yr) participated in the study. Bioavailability was assessed by pharmacokinetic parameters such as the area under plasma concentration-time curve from time zero up to the measurable last time point (AUC(last)) and the maximum plasma concentration (Cmax). Heparinized venous blood samples were collected pre-dose and up to a 48-hour period post-dose. Levothyroxine sodium in plasma samples was assayed by a validated electrochemiluninescent immunoassay technique. Statistical analysis showed that the post-dose thyrotropin-stimulating hormone (TSH) levels decreased significantly (p<0.05). Regarding Levothyroxine (T4), the point estimate of the test formulation to the reference formulation ratios (T/R) for AUC(last) and Cmax was 0.92 with 90% confidence limits (0.90, 0.94) and 0.93 with 90% confidence limits (0.91, 0.94), respectively. Regarding triiodo-L-thyronine (T3), the point estimate for the T/R ratios of AUC(last) and Cmax was 0.92 with 90% confidence limits (0.90, 0.95) and 0.94 with 90% confidence limits (0.92, 0.95), respectively. The 90% confidence limits for the pharmacokinetic parameters AUC(last) and Cmax lie within the acceptance limits for bioequivalence (0.80, 1.25), for both T3 and T4.

show abstract

Statistical assessment of the synergistic effect between a vaccine and a drug

Cited by 2 publications

References 2 publications

Discrimination of exudative pleural effusions based on multiple biological parameters

Discrimination of exudative pleural effusions based on multiple biological parameters

A bioequivalence study of Levothyroxine tablets versus an oral Levothyroxine solution in healthy volunteers

Contact Info

Product

Resources

About