Statistical Assessment of Time-Varying Dependency Between Two Neurons

Ventura, Valérie; Cai, Can

doi:10.1152/jn.00645.2004

Cited by 40 publications

(46 citation statements)

References 14 publications

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“…Methods to obtain peak correlations between neuron pairs using Matlab were the same as those we reported previously (Reed et al 2008), in which the cross-correlation histogram is derived from joint peristimulus time histogram (JPSTH) analysis (e.g., Aertsen et al 1989;Gerstein et al 1989;Ventura et al 2005), with all spike trains aligned with stimulus onset, similar to other studies of somatosensory cortex (Blake et al 2005;Ghoshal et al 2009;Roy and Alloway 1999;Roy et al 2001Roy et al , 2007Alloway 2004, 2006). To quantify spike timing synchrony with the JPSTH, small bin sizes between 1 and 5 ms are often used so that each bin contains 1 spike or less (e.g., Aertsen et al 1989;Alloway et al 2002;Gerstein et al 1989;Oram et al 2001;Roy et al 2007).…”

Section: Discussionmentioning

confidence: 99%

Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex

Reed

Pouget

et al. 2012

Journal of Neurophysiology

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Reed JL, Pouget P, Qi HX, Zhou Z, Bernard MR, Burish MJ, Kaas JH. Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex. J Neurophysiol 108: 3353-3369, 2012. First published September 26, 2012 doi:10.1152/jn.00414.2011The correlated discharges of cortical neurons in primary somatosensory cortex are a potential source of information about somatosensory stimuli. One aspect of neuronal correlations that has not been well studied is how the spatiotemporal properties of tactile stimuli affect the presence and magnitude of correlations. We presented single-and dual-point stimuli with varying spatiotemporal relationships to the hands of three anesthetized owl monkeys and recorded neuronal activity from 100-electrode arrays implanted in primary somatosensory cortex. Correlation magnitudes derived from joint peristimulus time histogram (JPSTH) analysis of single neuron pairs were used to determine the level of spike timing correlations under selected spatiotemporal stimulus conditions. Correlated activities between neuron pairs were commonly observed, and the proportions of correlated pairs tended to decrease with distance between the recorded neurons. Distance between stimulus sites also affected correlations. When stimuli were presented simultaneously at two sites, ϳ37% of the recorded neuron pairs showed significant correlations when adjacent phalanges were stimulated, and ϳ21% of the pairs were significantly correlated when nonadjacent digits were stimulated. Spatial proximity of paired stimuli also increased the average correlation magnitude. Stimulus onset asynchronies in the paired stimuli had small effects on the correlation magnitude. These results show that correlated discharges between neurons at the first level of cortical processing provide information about the relative locations of two stimuli on the hand. area 3b; hand; joint peristimulus time histogram; multi-electrode array; primate TACTILE SENSATIONS WE EXPERIENCE may be suppressed or utilized in our behavior. In a highly simplified experimental analogy, we stimulated two points simultaneously or asynchronously on different hand locations to examine the spatiotemporal stimulus effects on cortical populations in primary somatosensory cortex, area 3b, in three anesthetized New World owl monkeys. Our goal was to determine if spatial and temporal stimulus manipulations affect the presence and magnitude of spike timing correlations in predictable ways related to anatomical connectivity. We focused on correlated firing between pairs of area 3b neurons that may reflect common thalamic input arriving nearly simultaneously to nearby neurons, local intracortical and/or feedback connections within cortex, or both Spike timing correlations were shown to emerge in the 3b hand representations of two owl monkeys following long-term behavioral training in a touch detection task presented to adjacent digits (Blake et al. 2005). Receptive fields expanded, often to include sites on the two adjacent digits t...

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Section: Discussionmentioning

confidence: 99%

Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex

Reed

Pouget

et al. 2012

Journal of Neurophysiology

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“…Spike time synchrony. Spike synchrony between pairs of neurons was measured from the cross-correlation histogram derived from the JPSTH analysis with all spike trains aligned on the onset of skin indentation following previous conventions (6,11,41). See SI Text for detailed methods.…”

Section: Stimulation Proceduresmentioning

confidence: 99%

Widespread spatial integration in primary somatosensory cortex

Reed

Pouget²,

Qi³

et al. 2008

Proc. Natl. Acad. Sci. U.S.A.

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Tactile discrimination depends on integration of information from the discrete receptive fields (RFs) of peripheral sensory afferents. Because this information is processed over a hierarchy of subcortical nuclei and cortical areas, the integration likely occurs at multiple levels. The current study presents results indicating that neurons across most of the extent of the hand representation in monkey primary somatosensory cortex (area 3b) interact, even when these neurons have separate RFs. We obtained simultaneous recordings by using a 100-electrode array implanted in the hand representation of primary somatosensory cortex of two anesthetized owl monkeys. During a series of 0.5-s skin indentations with single or dual probes, the distance between electrodes from which neurons with synchronized spike times were recorded exceeded 2 mm. The results provide evidence that stimuli on different parts of the hand influence the degree of synchronous firing among a large population of neurons. Because spike synchrony potentiates the activation of commonly targeted neurons, synchronous neural activity in primary somatosensory cortex can contribute to discrimination of complex tactile stimuli.classical receptive field ͉ neuronal synchrony ͉ primate ͉ two-point stimulation ͉ Utah array H umans and other primates use their hands to make tactile discriminations that guide choices and actions. The vast majority of these choices are based on stimuli that are presented to sites across the hand or hands. Transformation of these scattered information sources from receptors in distinct patches of skin into one percept presumes integration within the central nervous system. This integration could occur at several levels, but here we consider the primary somatosensory cortex (S1 or area 3b). Though area 3b contains a detailed somatotopic representation of the hand and neurons with small receptive fields (RFs), considerable integration across hand locations may occur at this level via horizontal connections within area 3b.One way of examining neuronal interactions is through spike timing synchrony. When the spikes of two neurons occur together more often than expected by chance, we can infer that those neurons are part of the same local network. The two neurons may receive a common input that drives the synchronous firing, or the neurons may be synaptically connected. Our focus was on quantifying integration in anesthetized owl monkeys (Aotus trivirgatus) in the form of spike synchrony of neuronal activity in layers 2/3 of S1. Analysis of firing rate will be presented elsewhere.Using a 100-electrode array (Cyberkinetics) covering 4 mm ϫ 4 mm of cortical area ( Fig. 1 A and B), we examined sensory input integration in the area 3b hand representation by focusing on correlations in spike timing in pairs of neurons responding to the same or different stimulus probes (1-mm-diameter contact surface). We examined interactions across, rather than within, digit and palm pads to determine the extent of spatial integration in the area 3b hand rep...

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“…Eventually, one should reduce the comparison to an acceptable statistical format, such as a p-value, or perhaps a collection of p-values (maybe one for each lag in the CCH). See [7,72] for some specific suggestions. For graphical displays, one can represent the null variability as acceptance bands around the observed CCH.…”

Section: Acceptance Bandsmentioning

confidence: 99%

“…The bands indicate the middle 95% of CCH values under the null hypothesis of independence. A similar method may be applied in the non-Poisson case, using estimated conditional intensity functions based on the internal history [72].…”

Section: Independent Inhomogeneous Poisson Process (Ipp) Modelmentioning

confidence: 99%

- Spike Trains as Event Sequences: Fundamental Implications

2013

Spike Timing

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Statistical Assessment of Time-Varying Dependency Between Two Neurons

Cited by 40 publications

References 14 publications

Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex

Effects of spatiotemporal stimulus properties on spike timing correlations in owl monkey primary somatosensory cortex

Widespread spatial integration in primary somatosensory cortex

- Spike Trains as Event Sequences: Fundamental Implications

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