Equatorial plasma bubbles (EPBs) are plasma density depletions, which initiate in the equatorial or low-latitude F-region ionosphere bottom side and grow to the topside in the form of magnetic field-aligned structures. They usually occur after local sunset, when the conductivity at the E-region ionosphere becomes negligible that creates a favorable condition for the EPBs development. Density gradient at the EPBs boundaries may cascade into irregularities with a wide range of scale sizes, ranging from 10 −2 to 10 5 m (Kelley, 1989), and thus could affect the radio waves spanning a wide frequency range. Different terms have been used to characterize the F-region irregularities observed by different instruments, such as "spread F" in ionosonde observation, "plumes" of field-aligned irregularities (FAIs) in radar backscatter observations, and density "depletions" or "bite-outs" in in situ satellite observations. The dynamics and characteristics of the ionospheric irregularities have been extensively studied for many decades due to its adverse impact on radio communication and navigation systems between satellites and ground. Studies have been carried out to investigate the occurrence characteristics of the F-region irregularities by using data from various equipment, such as coherent and incoherent scatter radars, ionosonde, low-Earth orbiting satellite, radio scintillation detector, and airglow imager (e.g.