Pretrial assessment instruments provide courtroom actors with information about the likelihood that someone who has been charged with a criminal offense would engage in criminal behavior if released prior to trial. Although prior research supports the ability of pretrial instruments to predict pretrial outcomes, there are concerns that pretrial instruments may inadvertently exacerbate racial-ethnic and sex disparities found in the larger criminal legal system. In the current study, we conduct multi-site predictive bias tests of a widely used pretrial instrument—the Public Safety Assessment (PSA)—across six racial-ethnic and sex groups (i.e., White males, White females, Black males, Black females, Hispanic males, and Hispanic females). Study results support the PSA as a valid and consistent predictor of failure to appear, new criminal activity, and new violent criminal activity across these six racial-ethnic and sex groups. These findings support the use of the PSA and identify several areas for future research.