This paper uses relevant mathematical statistical models to verify the interactive effect between population mobility and the high-quality development of the manufacturing industry based on the panel data of 43 counties in the Fujian province from 2007 to 2021. The results show that (1) the inflow areas of population flow in the Fujian province are mainly concentrated in the southeast region; (2) there is mutual promotion between population mobility and the high-quality development of the manufacturing industry in the Fujian province, and the population mobility in adjacent areas has a significant promotion effect on the high-quality development of the local manufacturing industry; and (3) heterogeneity results show that after 2011, the interaction effect between population mobility and the high-quality development of the manufacturing industry has declined, and population inflow has a stronger role in promoting the high-quality development of the manufacturing industry than population outflow. The conclusions of this study are of great significance to the Fujian province for implementing a reasonable population policy and promoting the coordinated development of manufacturing enterprises.