Statistical Megamer Morphologies and Materials from PAMAM Dendrimers

Abstract

Summary: Generation‐4 poly(amidoamine) dendrimers (G4‐PAMAM) were cross‐linked using gluteraldehyde to obtain aldehyde‐activated G4‐PAMAM and cross‐linked G4‐PAMAM, termed pre‐megamers, which were grafted with octadecylamine (ODA) in chloroform (CHCl3). Statistical megamer morphologies and particles were prepared by an emulsification solvent‐evaporation method using an ODA‐premegamer/CHCl3 solution, surfactant, and water. Physicochemical characterization of the premegamers and megamers by various spectroscopic and microscopic techniques demonstrated their formation and properties useful in diagnostic and chromatographic applications.Formation of pre‐megamers and megamers and their transmission electron microscopy images.imageFormation of pre‐megamers and megamers and their transmission electron microscopy images.

Mixed-Generation PAMAM G3-G0 Megamer as a Drug Delivery System for Nimesulide: Antitumor Activity of the Conjugate Against Human Squamous Carcinoma and Glioblastoma Cells

“…PAMAM dendrimers can be stored in methanol at low temperatures, nonetheless, after several months, spontaneous aggregation of pristine dendrimers is observed [7]. The aggregation can be performed efficiently under chemical control using an appropriate linker, like glutaraldehyde [8,9], cyclooctyne-azide click coupling [10], or a straightforward reaction between variably terminated dendrimers, like G2-COOH and G2-NH 2 [7,11]. The stoichiometry and aggregation level in these procedures cannot be strictly controlled; therefore, high molecular weight dispersion of megamers is an inevitable feature.…”

Synthesis, Internalization and Visualization of N-(4-Carbomethoxy) Pyrrolidone Terminated PAMAM [G5:G3-TREN] Tecto(dendrimers) in Mammalian Cells

“…Within the context of architectural types, core-shell tecto(dendrimers) are well-defined dendri-clusters/assemblies and constitute a subset of poly(dendrimers) referred to as “megamers” [ 33 , 34 , 35 ]. The first examples of core-shell tecto(dendrimers) were reported by the Tomalia group in 1994 and 2002; however, they have received relatively little attention until the present.…”

PAMAM dendrimers as quantized building blocks for novel nanostructures

“…Assemblies utilizing dendrimers as the monomer units result in larger polymer-like structures or megamers. 16,17 Work in this eld has been pioneered by Tomalia [18][19][20][21] with the "tecto-dendrimer" strategy of self-assembling shell dendrimers around a core dendrimer followed by covalent cross-linking. This class of nanostructures utilizes steric hindrance to saturate the core dendrimer with various sized (i.e.…”