Statistical Methods for Evaluating the Efficacy of Screening Programs for Skin Cancer

Trampisch, Hans–Joachim; Windeler, Jürgen; Gebler, A.

doi:10.1007/978-3-642-60771-4_113

Cited by 1 publication

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In such a situation the average speci®city of 59.5% can be considered a good indicator of the diagnostic potential of the method for detecting the melanomas. Also the PPV of 17.5% is of the same order as the values reported for classical screening programs carried out in U.S.A. and the Netherlands [PPV 11% and 18% according to data presented by Trampisch et al (1997)]. It should be noticed, however, that according to other studies of screening programs from 35% to 50% of clinically diagnosed melanomas are con®rmed by histopathologic examinations (Bologna et al, 1990;Koh et al, 1990;Leffel et al, 1993;Wolf et al, 1996).…”

Section: Discussionsupporting

confidence: 73%

Fluorescence In Situ Detection of Human Cutaneous Melanoma: Study of Diagnostic Parameters of the Method

Chwirot

Sypniewska

et al. 2001

Journal of Investigative Dermatology

View full text Add to dashboard Cite

Multicenter study of the diagnostic parameters was conducted by three groups in Poland to determine if in situ fluorescence detection of human cutaneous melanoma based on digital imaging of spectrally resolved autofluorescence can be used as a tool for a preliminary selection of patients at increased risk of the disease. Fluorescence examinations were performed for 7228 pigmented lesions in 4079 subjects. Histopathologic examinations showed 56 cases of melanoma. A sensitivity of fluorescence detection of melanoma was 82.7% in agreement with 82.5% found in earlier work. Using as a reference only the results of histopathologic examinations obtained for 568 cases we found a specificity of 59.9% and a positive predictive value of 17.5% (melanomas versus all pigmented lesions) or 24% (melanomas versus common and dysplastic naevi). The specificity and positive predictive value found in this work are significantly lower than reported earlier but still comparable with those reported for typical screening programs. In conclusion, the fluorescence method of in situ detection of melanoma can be used in screening large populations of patients for a selection of patients who should be examined by specialists.

show abstract