2016
DOI: 10.1186/s40199-016-0142-0
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Statistical optimization of tretinoin-loaded penetration-enhancer vesicles (PEV) for topical delivery

Abstract: Background: The aim of this study was to develop and optimize deformable liposome for topical delivery of tretinoin. Methods: Liposomal formulations were designed based on the full factorial design and prepared by fusion method. The influence of different ratio of soy phosphatidylcholine and transcutol (independent variables) on incorporation efficiency and drug release in 15 min and 24 h (responses) from liposomal formulations was evaluated. Liposomes were characterized for their vesicle size and Differential… Show more

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Cited by 18 publications
(14 citation statements)
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“…Increased drug diffused in the skin, SC lipid fluidization, and increase in thermodynamic activity of drug in the skin and vehicles, as well as the effect on drug partition coefficient, are the most common mode of action of chemical enhancers. Ketorolac tromethamine (KT) is a non-steroidal anti-inflammatory drug (NSAID) with molecular formula C15H12NO3.C4H12NO3 [4]. It is one of the most potent NSAIDs.…”
Section: Introductionmentioning
confidence: 99%
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“…Increased drug diffused in the skin, SC lipid fluidization, and increase in thermodynamic activity of drug in the skin and vehicles, as well as the effect on drug partition coefficient, are the most common mode of action of chemical enhancers. Ketorolac tromethamine (KT) is a non-steroidal anti-inflammatory drug (NSAID) with molecular formula C15H12NO3.C4H12NO3 [4]. It is one of the most potent NSAIDs.…”
Section: Introductionmentioning
confidence: 99%
“…It is indicated to treat moderate-to-severe pain, and it has been studied in a broad spectrum of pain states such as post-partum and post-operative arthritic pain, pain of trauma, severe dental pain, and renal, biliary colic, and cancer, abdominal and Ä . X gical pain [6].…”
Section: Introductionmentioning
confidence: 99%
“…The optimized formulation (24:7) demonstrated an ~3.73-fold higher permeation flux (3.29±0.08 µg/cm 2 /h) across the rat skin as compared to the commercial cream (0.88±0.04 µg/cm 2 /h). 61 Several other miscellaneous drugs were reported to be delivered using EL, as summarized in Table 4.…”
Section: Photoprotective Agentsmentioning
confidence: 99%
“…13,59 Anti-psoriatic, anti-inflammatory, and antiacne drugs Currently, researchers have reported the management of acne, psoriasis, inflammation, and other cutaneous keratoses using colchicine, methotrexate, and tretinoin for topical delivery (Table 3). [59][60][61][62][63][64] with a desired set of goals. In brief, we have compiled limitations of these potent drugs in Table 3 that could be helpful for pharmaceutical scientists engaged in formulation design.…”
Section: Photoprotective Agentsmentioning
confidence: 99%
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