Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Brinkmann, Benjamin H.; Jones, David T.; Stead, Matt; Kazemi, Noojan; O’Brien, Terence J.; So, Elson L.; Blumenfeld, Hal; Mullan, Brian P.; Worrell, Gregory A.

doi:10.1038/jcbfm.2011.123

Cited by 18 publications

(7 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Taking into account that perfusion is 4 to 5-fold higher in gray matter than in white matter, this finding appears to conform with extensive asymmetry of gray matter density in healthy subjects, higher in the right hemisphere in the frontal and temporal cortex (Good et al, 2001). However, in a very recent study using a statistical parametric mapping approach very similar to the one used in the present study, Brinkmann and co-workers found larger HMPAO (and ECD) uptake in the left hemisphere compared with the right in neurologically normal volunteers (Brinkmann et al, 2011). The asymmetry affected widespread cortical areas, in good agreement with the present findings in mice (Fig.…”

Section: Lateral Asymmetrysupporting

confidence: 63%

Brain perfusion SPECT in the mouse: Normal pattern according to gender and age

et al. 2012

View full text Add to dashboard Cite

Section: Lateral Asymmetrysupporting

confidence: 63%

Brain perfusion SPECT in the mouse: Normal pattern according to gender and age

et al. 2012

View full text Add to dashboard Cite

“…In a recent study, Brinkmann et al [1] reported left > right perfusion asymmetry in widespread areas of the cerebral hemispheres in SPECT images of neurologically normal volunteers, based on examination of the images using semi-automated ROI analysis and statistical parametric mapping (SPM). In view of this previous report, our present results showing right > left rCBF asymmetry in patients with oral cenesthopathy could have important implications.…”

Section: Discussionmentioning

confidence: 99%

Brain perfusion asymmetry in patients with oral somatic delusions

Umezaki

Katagiri

Watanabe

et al. 2013

Eur Arch Psychiatry Clin Neurosci

View full text Add to dashboard Cite

Oral cenesthopathy is a somatic delusion or hallucination involving the oral area and is categorized as a delusional disorder, somatic type. The pathophysiology of this intractable condition remains obscure. In this study, we clarified the pathophysiology of oral cenesthopathy by evaluating regional brain perfusion. We performed single photon emission computed tomography (SPECT) using 99mTc-ethylcysteinate dimer in 16 subjects (cenesthopathy:control = 8:8). The SPECT images were visually assessed qualitatively, and quantitative analyses were also performed using a three-dimensional stereotactic region-of-interest template. The visual assessment revealed a right > left perfusion asymmetry in broad areas of the brain among the patients. The quantitative analysis confirmed that the regional cerebral blood flow values on the right side were significantly larger than those on the left side for most areas of the brain in the patients. A comparison of the R/(R + L) ratios in both groups confirmed the significant brain perfusion asymmetry between the two sides in the callosomarginal, precentral, and temporal regions in the patients. Qualitative evaluation of the SPECT images revealed right > left brain perfusion asymmetry in broad regions of the brain. Moreover, the quantitative analyses confirmed the perfusion asymmetry between the two sides in the frontal and temporal areas. Those may provide the key for elucidation of the pathophysiology of oral cenesthopathy.

show abstract

“…There was also less left-right asymmetry in our GRN mutation carriers, which we interpret as an indication of more marked metabolic abnormalities in the right hemisphere in light of reports of increased right-sided regional or global tracer uptake in normal subjects on FDG-PET and HMPAO SPECT. 14,23 These global abnormalities were present in both asymptomatic and CSND carriers. Concurrent localization with ROI and SPM analyses highlighted right medial and ventral regions in the frontal lobe.…”

Section: 56mentioning

confidence: 96%

Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers

et al. 2013

View full text Add to dashboard Cite

Objective: In this prospective cohort study, we investigated cerebral glucose metabolism reductions on [18 F]-fluorodeoxyglucose (FDG)-PET in progranulin (GRN) mutation carriers prior to frontotemporal dementia (FTD) onset.Methods: Nine mutation carriers (age 51.5 6 13.5 years) and 11 noncarriers (age 52.7 6 9.5 years) from 5 families with FTD due to GRN mutations underwent brain scanning with FDG-PET and MRI and clinical evaluation. Normalized FDG uptake values were calculated with reference to the pons. PET images were analyzed with regions of interest (ROI) and statistical parametric mapping (SPM) approaches.Results: Compared with noncarriers, GRN mutation carriers had a lowered anterior-to-posterior (AP) ratio of FDG uptake (0.86 6 0.09 vs 0.92 6 0.05) and less left-right asymmetry, consistent with an overall pattern of right anterior cerebral hypometabolism. This pattern was observed regardless of whether they were deemed clinically symptomatic no dementia or asymptomatic. Individual ROIs with lowered FDG uptake included right anterior cingulate, insula, and gyrus rectus. SPM analysis supported and extended these findings, demonstrating abnormalities in the right and left medial frontal regions, right insular cortex, right precentral and middle frontal gyri, and right cerebellum. Right AP ratio was correlated with cognitive and clinical scores (modified Mini-Mental State Examination r 5 0.74; Functional Rating Scale r 5 20.73) but not age and years to estimated onset in mutation carriers. Conclusion:The frontotemporal lobar degenerative process associated with GRN mutations appears to begin many years prior to the average age at FTD onset (late 50s-early 60s). Right medial and ventral frontal cortex and insula may be affected in this process but the specific regional patterns associated with specific clinical variants remain to be elucidated. The multifaceted clinical syndrome of frontotemporal dementia (FTD) arises from degeneration of the frontal and temporal lobes (frontotemporal lobar degeneration). Mutations in the gene encoding progranulin (GRN), discovered in 2006, 1,2 are found in 5%-20% of those with familial FTD (FTD-GRN).2,3 Despite the common haploinsufficiency mechanism 1 and transactive response DNA-binding protein M r 43 kD (TDP-43) neuropathology, 4 there is phenotypic variation in FTD-GRN, with behavioral variant FTD (bvFTD), progressive nonfluent aphasia (PNFA), and corticobasal syndrome.5 Mean age at onset is 59-65 years, but can range from 35 to 87 years. 6 In GRN mutation carriers with FTD, an asymmetric pattern of brain structural abnormalities is found, with severe gray matter loss involving frontal, anterior temporal, but also posterior temporal and inferior parietal regions. [7][8][9] There is only very limited evidence on brain

show abstract

Statistical Parametric Mapping Demonstrates Asymmetric Uptake with Tc-99m ECD and Tc-99m HMPAO SPECT in Normal Brain

Cited by 18 publications

References 42 publications

Brain perfusion SPECT in the mouse: Normal pattern according to gender and age

Brain perfusion SPECT in the mouse: Normal pattern according to gender and age

Brain perfusion asymmetry in patients with oral somatic delusions

Anterior brain glucose hypometabolism predates dementia in progranulin mutation carriers

Contact Info

Product

Resources

About