An increasing emphasis on the industrial-scale implementation of Carbon dioxide (CO 2) storage in geological formations has led to the development of whole-system models to evaluate performance of candidate geologic storage sites and the environmental risk associated with them. Components of that engineered geologic system include the storage reservoir, overlying aquitards (primary caprock and secondary seals) and aquifers (including the above zone monitoring interval, or AZMI, directly overlying the primary seal), and potential leakage pathways including wells, fractures, and faults. Leakage of CO 2 and brine through the primary seal to the overlying porous and permeable formations (AZMI) may occur due to the seal's intrinsic permeability and/or the presence of natural fractures or induced perforations or fractures in the caprock. AZMI monitoring may provide a potentially useful source of information about seal performance and subsurface pressure response to potential CO 2 and/or brineleakage from the reservoir. Unfortunately, full complexity simulations of the geologic storage system are not computationally affordable, especially given the need to develop many realizations to