In modern industrial production processes, process monitoring plays a major role in improving process efficiency and quality of product, and it is an important task in industrial process. The best way to implement process monitoring is to develop models that describe different phenomena in physics, chemistry, and processes. However, because the modeling of industrial processes is often very complex and has significant intrinsic nonlinearities, a reasonable theoretical modeling method are often impractical. With the adoption of distributed control systems, the application of multivariate statistical monitoring is becoming more and more popular in the distributed system environment. This paper uses the technology for multivariate monitoring of continuous production processes. Based on principal component analysis (PCA) and making full use of system statistics information, the method can well deal with the nonlinear and multimode distribution of industrial data, which is difficult to be dealt with by traditional methods. This method can be used not only in process detection but also in fault detection. Finally, the method is applied to the actual example and the Tennessee-Eastman model; the simulation results prove the feasibility of the proposed method and achieve better results.