Statistical Survey of Deaths from Nonmelanoma Skin Cancer in Japan during 54 Years

Ohtsuka, Hisashi

doi:10.1155/2011/293926

Cited by 8 publications

(7 citation statements)

References 21 publications

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“…Recurrence rate is also higher in immunosuppressed patients. In the present study, recurrence was documented in 13% of patients, in line with the 7%‐13% rate reported in previous studies . The median time to recurrence was 2 years.…”

Section: Discussionsupporting

confidence: 92%

“…In the present study, recurrence was documented in 13% of patients, in line with the 7%-13% rate reported in previous studies. 26,[40][41][42][43][44][45][46][47][48][49] The median time to recurrence was 2 years. Similarly, Martinez et al 45 reported a metastatic recurrence rate of 5%-8%, usually during the second year after surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…9,16 However, the effect of specific immunosuppressive agents remains unclear. 5,22,47 Azathioprine and cyclosporine have been associated with the development of skin cancer in multiple clinical studies. 13,17,20,[48][49][50] Immunosuppression with the mammalian target of rapamycin inhibitors Sirolimus and everolimus were associated with reduction in the risk of NMSC, 51 but have been recently linked to increased mortality.…”

Section: Discussionmentioning

confidence: 99%

“…The results of several studies suggest that the number of regimens, as well as the intensity and duration of immunosuppression influence the risk of developing NMSC . However, the effect of specific immunosuppressive agents remains unclear . Azathioprine and cyclosporine have been associated with the development of skin cancer in multiple clinical studies .…”

Section: Discussionmentioning

confidence: 99%

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Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

et al. 2018

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Background Nonmelanoma skin cancers (NMSC) are the most common malignancies in solid organ recipients. We investigated the incidence, clinical features, and outcome of solid organ recipients with NMSC of the head and neck. Methods A retrospective chart review was conducted for solid organ recipients who were treated from 1992 to 2015 and who developed NMSC of the head and neck. Results Of 3339 organ recipients, 259 patients developed 697 head and neck NMSC. Squamous cell carcinoma was the most common malignancy (55%). The overall 5‐year and 10‐year survival was 68% and 45%. Kidney recipients had better survival outcome than other organ recipients (10 vs 7 years). Advanced‐stage cancers (10%), aggressive patterns of tumors (21%), and treatment with Prograf and Cellcept were associated with increased disease‐specific mortality. Conclusion Solid organ transplant increases the risk of NMSC of the head and neck. Aggressive tumors decrease patient survival and warrant more decisive and multidisciplinary approach.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

et al. 2018

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“…NMSCs have been shown to be BCCs in 80% of instances, and 20% are SCCs [17]. Our BCC and SCC rates were observed to be close to these percentages.…”

Section: Discussionsupporting

confidence: 80%

Histopathological evaluation of non-melanoma skin cancer

Koyuncuer¹

2014

World J Surg Onc

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BackgroundNon-melanoma skin cancers (NMSCs) are the most frequently seen cancers worldwide.MethodsThe medical records of patients diagnosed with basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) in Hatay Antakya pathology laboratory between January 2010 and September 2012 were retrospectively included in the study. Tumors were categorized according to age, gender, anatomical localization, type, solitary-multiplicity, tumor diameter (0 to 2 mm, 2.1 to 6 mm and >6.1 mm), and presence of ulceration (BCCs), and morphological subtype, histopatological features and grades (SCCs).ResultsA total of 136 tumors in 127 NMSC cases were examined. Solitary tumors were seen in 118 (92.9%), and multiple tumors in 9 (7.1%) patients. Mean age of the patients was 68.5 ± 13 years. BCC was observed in 96 (75.6%) and SCC in 31 (24.4%) patients. Mean diameter of all types of solitary and multiple tumors was 7.42 ± 3.49 mm. Nodular subtype focal cystic changes were observed in 49 (47.6%) patients. All tumors (solitary and multiple) were seen on the face (67.6%), scalp (11.8%), and ear (11%). Well differentiated SCCs were detected in 20 cases (64.5%); ulceration was observed in 58.1% of all tumors.ConclusionsEpidemiologic and histopathological investigations, routine skin scanning performed on the elderly population and dermatological examination will help to improve efficient health applications.

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Solid organ transplantation worsens the prognosis of patients with cutaneous squamous cell carcinoma of the head and neck region—Comparison between solid organ transplant recipients and immunocompetent patients

et al. 2020

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Background Cutaneous squamous cell carcinoma of the head and neck (CSCC‐HN) appears to behave more aggressively in immunosuppressed patients. We aimed to investigate this hypothesis by comparing solid organ transplant recipients (SOTR) with CSCC‐HN to immunocompetent patients. Methods A retrospective comparative study was conducted for SOTR and immunocompetent patients who were treated for CSCC‐HN. Results A total of 177 SOTR and 157 immunocompetent patients with CSCC‐HN were included. Lymph node metastases were more common in the SOTR group (9% vs 3%), and distant metastases occurred only in SOTR (3% of patients). SOTR had a higher rate of recurrences (19% vs 10%), which were mostly regional (7%) and distant (3%). The 2‐year disease‐specific survival of SOTR was lower (93% vs 100%). Conclusions SOTR with CSCC‐HN has significantly worse outcomes compared to immunocompetent patients. Solid‐organ transplantation should be regarded as a negative prognostic factor in patients with CSCC‐HN.

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Statistical Survey of Deaths from Nonmelanoma Skin Cancer in Japan during 54 Years

Cited by 8 publications

References 21 publications

Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

Nonmelanoma skin cancer of the head and neck region in solid organ transplant recipients

Histopathological evaluation of non-melanoma skin cancer

Solid organ transplantation worsens the prognosis of patients with cutaneous squamous cell carcinoma of the head and neck region—Comparison between solid organ transplant recipients and immunocompetent patients

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