Statistically Biased Calibration Method for the Real-time Adjustment of Noninvasive Haemoglobin Measurements in a Semi-automated Infusion System

Markevičius, Vytautas; Andrijauskas, Audrius; Navikas, Dangirutis; Svensén, Christer; Porvaneckas, Narūnas; Andriukaitis, Darius; Kvederas, Giedrius; Činčikas, Darius; Andrijauskas, Paulius

doi:10.5755/j01.eee.19.7.5165

Cited by 5 publications

(7 citation statements)

References 17 publications

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“…We used the findings of our present study to upgrade the mVLT algorithm ( Fig. 6) in our Windows ® platform-based software of the prototype SCLIS [3]- [5] (Fig. 7).…”

Section: Discussionmentioning

confidence: 99%

“…1) and acPED (Fig. 2) using the Windows ® platformbased software of our prototypes ACDSS and SCLIS [3]- [5].…”

Section: Methodsmentioning

confidence: 99%

“…Previously, data from 36 subjects who received three 5 ml kg -1 boluses have been published addressing blood loss [7], accuracy of non-invasive SpHb measurements [3] and the use of the mVLT to detect pre-operative dehydration [2].…”

Section: Conflict Of Interestsmentioning

confidence: 99%

“…The assessment of hemodilution response requires hemoglobin measures before and after each mini fluid challenge (MFC). Hemoglobin in arteries (invasive, aHb) and capillaries (non-invasive, SpHb) are used to calculate the arterial and capillary plasma dilution efficacies (aPDE and cPDE, respectively) and arteriocapillary plasmadilution efficacy difference (acPED) [1], [3]. Based on observations in healthy volunteers [1] and patients [2], a transcapillary reflux model suggests that acPED ≤ 0 p.d.u.…”

Section: Introductionmentioning

confidence: 99%

“…This signifies that fluid loading should be stopped. However, the need for invasive measurements is a major drawback in the clinical implication of our novel automated clinical decision support system (ACDSS) and the SCLIS [3]- [5]. A solely noninvasive assessment of hemodilution response would be possible if the cPDE could reliably predict the acPED value or the hemodilution response (the presence of acPED value within a range of acPED > 0) or non-response (acPED ≤ 0).…”

Section: Introductionmentioning

confidence: 99%

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Revised Evaluation of Hemodilution Response in the Semi-Closed Loop Infusion System

Markevičius¹,

Činčikas²,

Porvaneckas³

et al. 2016

ElAEE

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A mini volume loading test (mVLT) method is used for decision making in our prototype semi-closed loop infusion system (SCLIS). The mVLT fluid protocol consists of hemodilution response-guided mini fluid challenges. Each mini fluid challenge (MFC) consists of a 2.5 ml kg-1-5 ml kg-1 crystalloid bolus infused over 2 min-5 min and followed by a 5 min period with no fluids. Arterial plasma dilution efficacy (aPDE) of a MFC is calculated from invasively measured hemoglobin (aHb) before and after each MFC. Capillary plasma dilution efficacy (cPDE) is calculated from noninvasively measured hemoglobin (SpHb). The zero or negative arterio-capillary plasmadilution efficacy difference (acPED ≤ 0 p.d.u.) is an indication of hemodilution non-response and imminent edema. However, it requires both invasive and noninvasive hemoglobin measurements. A non-invasive assessment of hemodilution response within the mVLT method would increase its practical application and reduce costs further enhancing its applicability in the SCLIS. This possibility exists if the cPDE could reliably predict the acPED value or the hemodilution response (the presence of acPED within a range of > 0) or non-response (acPED ≤ 0). We report a retrospective observational study in an elective total knee arthoplasty (TKA) setting. The 2.5 ml kg-1 boluses were used in six MFCs in both pre-and post-operative mVLT sessions. The primary objective was to assess the accuracy of cPDE in predicting the hemodilution response using the receiver operating characteristic (ROC) curve and gray zone approaches. Our secondary objective was to investigate the feasibility of a statistical optimization method (SOM) in predicting the acPED. The analysis included 480 paired values of cPDE and acPED. The best cutoff value for cPDE was 0.015 p.d.u. (specificity = 0.84, sensitivity = 0.90). The gray zone identified a range of cPDE values between 0.013 and 0.028 (p.d.u.) for which the hemodilution response could not be indicated reliably. The 14 % of the cPDE values were in this range.

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“…We used the findings of our present study to upgrade the mVLT algorithm ( Fig. 6) in our Windows ® platform-based software of the prototype SCLIS [3]- [5] (Fig. 7).…”

Section: Discussionmentioning

confidence: 99%

“…1) and acPED (Fig. 2) using the Windows ® platformbased software of our prototypes ACDSS and SCLIS [3]- [5].…”

Section: Methodsmentioning

confidence: 99%

Section: Conflict Of Interestsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Revised Evaluation of Hemodilution Response in the Semi-Closed Loop Infusion System

Markevičius¹,

Činčikas²,

Porvaneckas³

et al. 2016

ElAEE

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Two thermocouples low power wireless sensors network

Markevičius

Navikas

Andriukaitis

et al. 2018

AEU - International Journal of Electronics and Communications

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This paper presents technologies and experiments of a wireless sensors using two thermocouples network. It was established that the energy consumption during sensor measurements is usually up to 10 times lower compared to the energy consumption at the time of establishing wireless connection for most protocols. For this reason, new simplified wireless connection protocol was created. Extremely low energy wireless sensor hardware and software equipment was designed. The newly created universal measurement module allows the use not only thermocouples, but also various types of analogue sensors, thermocouples, pressure bridges, Resistance Temperature Detectors (RTD) and digital sensors communicating through SPI or I2C interface. The newly designed specific power supply scheme allows to supply the sensor and radio module with the voltage from 1.2 V to 3.6 V batteries. When conducting periodic measurements every second, the use of newly designed hardware and software equipment enables the wireless sensor to be operated for up to 3 years from two 1200 mAh capacity batteries.

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A mini volume loading test for indication of preoperative dehydration in surgical patients

et al. 2015

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Statistically Biased Calibration Method for the Real-time Adjustment of Noninvasive Haemoglobin Measurements in a Semi-automated Infusion System

Cited by 5 publications

References 17 publications

Revised Evaluation of Hemodilution Response in the Semi-Closed Loop Infusion System

Revised Evaluation of Hemodilution Response in the Semi-Closed Loop Infusion System

Two thermocouples low power wireless sensors network

A mini volume loading test for indication of preoperative dehydration in surgical patients

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