Statistische Befunde zur Klinik der Huntingtonschen Chorea

Oepen, Heinrich; Landzettel, H. J.; Streletzki, R.; Koppenfels, I. v.

doi:10.1007/bf00343021

Cited by 11 publications

(2 citation statements)

References 19 publications

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“…Pregnancy has been suggested several times (Tieke, 1934;Panse, 1942;Spengler, 1956) as a possible agent provocateur, but the work of Oepen et al (1963) and the independence of age of onset and sex (Brackenridge, 1971) argue against its promi-This work was supported by a grant from the National Health and M'edical Research Council of Australia. 297 nence.…”

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confidence: 99%

Effect of climatic temperature on the age of onset of Huntington's chorea

Brackenridge

1974

Journal of Neurology, Neurosurgery & Psychiatry

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SYNOPSIs The ages of 1,403 subjects at onset of Huntington's chorea were drawn from the literature and related to the mean annual, January, and July temperatures of their place of residence. When the data were converted into mean annual, winter, and summer isotherms covering a range of 10°F (5*6°C), there was a statistically significant decrease in age of onset as the temperature increased. Over the ranges studied, winter temperatures exerted a stronger effect than summer temperatures. To reduce interference by ethnic factors, the analysis was repeated on North American subjects with similar results. It is suggested that repeated infections may provoke chorea and that the observed lowering of the age of onset is associated with increased susceptibility to infection on passing from cold to warm climates.

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confidence: 99%

Effect of climatic temperature on the age of onset of Huntington's chorea

Brackenridge

1974

Journal of Neurology, Neurosurgery & Psychiatry

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“…Those factors explored include the type of neurological sign predominating [2,3], the order of appearance of neurological and psychiatric symptoms [3,8], the sex of the subject and of the affected parent [3,7], allelic genes [4,6] and parental onset age [1,5,9]. Several of these have emerged as important determinants but no simple pattern of their mutual relationship has been described.…”

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confidence: 99%