Hydrokinetic turbines are one of the technological alternatives to generate and supply electricity for rural communities isolated from the national electrical grid with almost zero emission. These technologies may appear suitable to convert kinetic energy of canal, river, tidal, or ocean water currents into electricity. Nevertheless, they are in an early stage of development; therefore, studying the hydrokinetic system is an active topic of academic research. In order to improve their efficiencies and understand their performance, several works focusing on both experimental and numerical studies have been reported. For the particular case of flow behavior simulation of hydrokinetic turbines with complex geometries, the use of computational fluids dynamics (CFD) nowadays is still suffering from a high computational cost and time; thus, in the first instance, the analysis of the problem is required for defining the computational domain, the mesh characteristics, and the model of turbulence to be used. In this chapter, CFD analysis of a H-Darrieus vertical axis hydrokinetic turbines is carried out for a rated power output of 0.5 kW at a designed water speed of 1.5 m=s, a tip speed ratio of 1.75, a chord length of 0.33 m, a swept area of 0.636 m 2 , 3 blades, and NACA 0025 hydrofoil profile.