Status Epilepticus

Jordan, Kenneth G.

doi:10.1016/s1042-3680(18)30494-7

Cited by 39 publications

(1 citation statement)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 17 , 19 The time frame of 30 minutes was based on the duration of convulsive SE that is required to cause permanent complications and neuronal injury. 9 , 10 , 17 , 18 , 20 However, because the majority of seizures are brief, and once a seizure lasts >5 minutes, it is most likely to be prolonged and potentially non‐self‐limiting, 21 researchers and clinicians have broadly adopted and accepted the 5‐minute time frame as the defining element of SE. The aim of this 5‐minute cut‐off time is to (i) minimize the risk of systemic and brain complications associated with continuous seizure activity reaching up to 30 minutes, (ii) prevent worsening of the prognosis and drug resistance associated with increasing duration of uncontrolled seizure activity, and (iii) limit any potentially unfavorable outcomes and adverse effects associated with the prolonged administration of multiple therapeutic (including anesthetic) interventions for seizures that are brief and self‐limiting.…”

Section: Definition and Classificationmentioning

confidence: 99%

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats

Charalambous,

Muñana,

Patterson

et al. 2023

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundSeizure emergencies (ie, status epilepticus [SE] and cluster seizures [CS]), are common challenging disorders with complex pathophysiology, rapidly progressive drug‐resistant and self‐sustaining character, and high morbidity and mortality. Current treatment approaches are characterized by considerable variations, but official guidelines are lacking.ObjectivesTo establish evidence‐based guidelines and an agreement among board‐certified specialists for the appropriate management of SE and CS in dogs and cats.AnimalsNone.Materials and MethodsA panel of 5 specialists was formed to assess and summarize evidence in the peer‐reviewed literature with the aim to establish consensus clinical recommendations. Evidence from veterinary pharmacokinetic studies, basic research, and human medicine also was used to support the panel's recommendations, especially for the interventions where veterinary clinical evidence was lacking.ResultsThe majority of the evidence was on the first‐line management (ie, benzodiazepines and their various administration routes) in both species. Overall, there was less evidence available on the management of emergency seizure disorders in cats in contrast to dogs. Most recommendations made by the panel were supported by a combination of a moderate level of veterinary clinical evidence and pharmacokinetic data as well as studies in humans and basic research studies.Conclusions and Clinical RelevanceSuccessful management of seizure emergencies should include an early, rapid, and stage‐based treatment approach consisting of interventions with moderate to preferably high ACVIM recommendations; management of complications and underlying causes related to seizure emergencies should accompany antiseizure medications.

show abstract

Section: Definition and Classificationmentioning

confidence: 99%

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats

Charalambous,

Muñana,

Patterson

et al. 2023

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

Identification and treatment of acute repetitive seizures in children and adults

Cereghino

2007

Curr Treat Options Neurol

View full text Add to dashboard Cite

Acute repetitive seizures are a predictable component of a patient's seizure disorder, historically distinct from the patient's other epileptic seizures in type, frequency, severity, or duration, and with an onset easily recognized by caregiver and physician. Onset has a consistent predictable component (such as aura or prodrome, which may be a convulsive or nonconvulsive symptom, or characteristic single or multiple seizures) that is predictably and temporally linked to subsequent seizures. Typically there is recovery between seizures. Episodes may or may not progress to a prolonged seizure or to status epilepticus but may be predictable for each patient based on history. Acute repetitive seizures may include any type of epileptic seizure and may occur at any age. Other terms for acute repetitive seizures include cluster, serial, recurrent, or crescendo seizures. Treatment should only be administered by caregivers who in the opinion of the prescriber are capable of monitoring the clinical response and recognize when the response is such that immediate professional evaluation or care is necessary. Caregivers must be comfortable so that they feel capable of recognizing when and how to treat. The prescriber and caregiver should have a written plan on when to treat and what to observe and do after treatment. The most immediate treatment for out of hospital care and the only US Food and Drug Administration-approved product for acute repetitive seizures is rectal diazepam gel administered at a dose of 0.2 to 0.5 mg/kg, depending on age and weight (Class I evidence). Treatment may produce central nervous system depression. Oral, buccal, and sublingual benzodiazepines (lorazepam, diazepam) are also used for treatment but only if the risk of aspiration is not a concern and recognizing that absorption time will be increased (Class III evidence). Nasal benzodiazepine products, available in some countries, are not yet available in the United States.

show abstract

Management of Status Epilepticus in Neurological Versus Medical Intensive Care Unit: Does it Matter?

et al. 2013

View full text Add to dashboard Cite

show abstract

Status Epilepticus

Cited by 39 publications

References 38 publications

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats

ACVIM Consensus Statement on the management of status epilepticus and cluster seizures in dogs and cats

Identification and treatment of acute repetitive seizures in children and adults

Management of Status Epilepticus in Neurological Versus Medical Intensive Care Unit: Does it Matter?

Contact Info

Product

Resources

About