Status epilepticus: An association with pyrethroid poisoning

Panwar, Mamta; Usha, G; Kumath, Manish

doi:10.4103/0972-5229.114825

Cited by 13 publications

(11 citation statements)

References 6 publications

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“…However, pyrethrins and pyrethroids are generally benign to mammals due to their negligible action on mammalian enzymes, as well as their lack of persistence in the environment 2. Generally, only a small body of literature describes human toxicity, which, when it does occur, is commonly a result of dermal exposure or intentional ingestion 3 4…”

Section: Discussionmentioning

confidence: 99%

Clinical effects from household insecticide: pyrethroid or organophosphate toxicity?

et al. 2019

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A 54-year-old man with a history of schizophrenia presented to the emergency room for weakness with associated lacrimosis, drooling, nausea, emesis, diarrhoea, diplopia and burning sensation on his skin that began 6 hours after spraying five cans of Raid on his carpet. He was noted to have miotic pupils and hyperactive bowel sounds. Given the clinical presentation, the patient was diagnosed with organophosphate (OP) toxicity. After being admitted, he developed symptoms associated with his OP toxicity and was successfully treated with atropine and pralidoxime. Most Raid products contain pyrethroids; however, both OPs and pyrethroids are available in commercial pesticides and patients may misidentify ingestions. There are limited data reporting the toxicity of pyrethroid overdose in humans and to guide its subsequent treatment. It is crucial to keep a low threshold for diagnosing and treating patients with acute onset of symptoms suspicious for an OP or pyrethroid toxidrome.

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Section: Discussionmentioning

confidence: 99%

Clinical effects from household insecticide: pyrethroid or organophosphate toxicity?

et al. 2019

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“…[1] along with literature support. The authors have also stressed that the practitioners shall consider this entity in the differential diagnosis of poisoning with seizures.…”

mentioning

confidence: 83%

“…Seizures following pyrethroid ingestion and its non-responsiveness to anticonvulsants were lamented by Panwar et al . [ 1 ] along with literature support. The authors have also stressed that the practitioners shall consider this entity in the differential diagnosis of poisoning with seizures.…”

mentioning

confidence: 88%

The anticonvulsant of choice in pyrethroid induced convulsions

Balamurugan

Menezes

Thirumalaikolundusubramanian³

2014

Indian Journal of Critical Care Medicine

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“…The efficacy and safety of a diet supplemented with a high-dose EPA and DHA (9 g/d added to 1 g/d ascorbic acid, 400UI/12 h α-tocopherol and 100 μg/d selenium) was assessed in patients with early-stage sepsis for 7 days. The investigators found patients had lower levels of CRP, IL-6 and procalcitonin, as well as less need for mechanical ventilation and reduced development of severe sepsis ( Hosny, Nahas, Ali, Elshafei, & Khaled, 2013 ). Evidence for beneficial effects of n-3 PUFA-containing diets in patients with severe ARDS demonstrated similar outcomes such as reduced duration of mechanical ventilation, shorter ICU length and improved oxygenation ( Langlois, D'Aragon, Hardy, & Manzanares, 2019 ).…”

Section: Role Of N-3 Polyunsaturated Fatty Acids In Patients With Resmentioning

confidence: 99%

Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

Darwesh

Bassiouni

Sosnowski

et al. 2021

Pharmacology & Therapeutics

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Coronavirus disease 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), has currently led to a global pandemic with millions of confirmed and increasing cases around the world. The novel SARS-CoV-2 not only affects the lungs causing severe acute respiratory dysfunction but also leads to significant dysfunction in multiple organs and physiological systems including the cardiovascular system. A plethora of studies have shown the viral infection triggers an exaggerated immune response, hypercoagulation and oxidative stress, which contribute significantly to poor cardiovascular outcomes observed in COVID-19 patients. To date, there are no approved vaccines or therapies for COVID-19. Accordingly, cardiovascular protective and supportive therapies are urgent and necessary to the overall prognosis of COVID-19 patients. Accumulating literature has demonstrated the beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFA) toward the cardiovascular system, which include ameliorating uncontrolled inflammatory reactions, reduced oxidative stress and mitigating coagulopathy. Moreover, it has been demonstrated the n-3 PUFAs, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), are precursors to a group of potent bioactive lipid mediators, generated endogenously, which mediate many of the beneficial effects attributed to their parent compounds. Considering the favorable safety profile for n-3 PUFAs and their metabolites, it is reasonable to consider n-3 PUFAs as potential adjuvant therapies for the clinical management of COVID-19 patients. In this article, we provide an overview of the pathogenesis of cardiovascular complications secondary to COVID-19 and focus on the mechanisms that may contribute to the likely benefits of n-3 PUFAs and their metabolites.

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Status epilepticus: An association with pyrethroid poisoning

Abstract: This report describes a 35 year old male who presented with seizures after consuming 4-5 bottles of “ALL-OUT” a commercial composition of pyrethroid used as insecticides. Our case report supports authors reporting an association of pyrethroid poisoning with status epilepticus.

Cited by 13 publications

References 6 publications

Clinical effects from household insecticide: pyrethroid or organophosphate toxicity?

Clinical effects from household insecticide: pyrethroid or organophosphate toxicity?

The anticonvulsant of choice in pyrethroid induced convulsions

Can N-3 polyunsaturated fatty acids be considered a potential adjuvant therapy for COVID-19-associated cardiovascular complications?

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